809285-62-9

Upstream product

• 2746-25-0 p-Methoxybenzyl bromide 
• 185148-92-9 (S)-2-(2,2-dimethyl-<1,3>dioxan-4-yl)-2-methylpropionaldehyde 
• 220367-70-4 (4S)-4-(2-methyl-1-hydroxyprop-2-yl)-2,2-dimethyl[1,3]dioxane 
• 370578-47-5 (S)-naphthalne-2-carboxylic acid 3-hydroxy-2,2-dimethyl-hex-5-enyl ester 
• 809285-80-1 2-[(4S)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methylhex-4-en-3-ol 
• 809285-66-3 (3S)-2-{(4S)-2,2-dimethyl-[1,3]dioxan-4-yl}-2-methylhex-4-yn-3-ol 
• 809285-72-1 2-[(2R)-4-bromo-2-methoxybut-3-ynyl]oxazole-4-carboxylic acid methyl ester 
• 809285-64-1 2-[(2R)-4-iodo-2-methoxybut-3-enyl]oxazole-4-carboxylic acid methyl ester 
• 809285-65-2 (3R)-5-(triisopropylsilyloxy)-1-(trimethylsilyl)pent-1-yn-3-ol 
• 809285-78-7 (3S)-naphthalene-2-carboxylic acid 3,5-dihydroxy-2,2-dimethylpentyl ester 
• 809285-68-5 (3S,5S)-5-(4-methoxybenzyloxy)-4,4-dimethyloct-6-ene-1,3-diol 
• 809285-79-8 naphthalene-2-carboxylic acid 2-[(4S)-2,2-dimethyl-[1,3]dioxan-4-yl]-2-methylpropyl ester 

Relevant academic research and scientific papers

Self-Assembly of Disorazole C1 through a One-Pot Alkyne Metathesis Homodimerization Strategy

Abstract Alkyne metathesis is increasingly explored as a reliable method to close macrocyclic rings, but there are no prior examples of an alkyne-metathesis-based homodimerization approach to natural products. In this approach to the cytotoxic C2-symmetric marine-derived bis(lactone) disorazole C1, a highly convergent, modular strategy is employed featuring cyclization through an ambitious one-pot alkyne cross-metathesis/ring-closing metathesis self-assembly process.