80937-24-2

Usage

Uses

Used in Scientific Research and Development:
(E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid is used as a research compound for the synthesis of various pharmaceuticals and organic compounds. Its unique structure, which includes a nitro group, a phenyl group, and a carboxylic acid group, makes it a valuable starting material for the development of new chemical entities.
Used in Organic Synthesis:
In the field of organic synthesis, (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid is used as a key intermediate for the creation of complex organic molecules. Its functional groups can be manipulated to form a wide range of products, making it a versatile building block in the synthesis of various compounds.

InChI:InChI=1/C10H7NO5/c12-9(5-6-10(13)14)7-3-1-2-4-8(7)11(15)16/h1-6H,(H,13,14)/b6-5+

Upstream product

• 141-82-2 malonic acid 
• 58950-89-3 (2-nitrophenyl)glyoxal 
• 577-59-3 2-acetylnitrobenzene 
• 563-96-2 2,2-dihydroxyacetic acid 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 35402-55-2 4-(2-aminophenyl)-4-oxobutanoic acid 
• 1056025-76-3 2-acetylsulfanyl-4-(2-nitrophenyl)-4-oxobutanoic acid 

Relevant academic research and scientific papers

Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents

A series of novel (E)-4-oxo-2-crotonamide derivatives were designed and synthesized to find potent antituberculosis agents. All the target compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv(MTB). Results reveal that 4-phenyl moiety at part A and short methyl group at part C were found to be favorable. Most of the derivatives displayed promising activity against MTB with MIC ranging from 0.125 to 4 μg/mL. Especially, compound IIIa16 was found to have the best activity with MIC of 0.125 μg/mL against MTB and with MIC in the range of 0.05–0.48 μg/mL against drug-resistant clinical MTB isolates.

CoA adducts of 4-oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis menaquinone biosynthesis pathway

A high-throughput screen led to the discovery of 2-amino-4-oxo-4- phenylbutanoate inhibitors of the 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) from the menaquinone biosynthesis pathway in Mycobacterium tuberculosis. However, these compounds are unstabl

First total synthesis of the antifungal antibiotic thiobutacin

The first total synthesis of thiobutacin, a butanoic acid with antifungal activity recently isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9, is described. The five-step procedure involves readily availabl

Novel human lens metabolites from normal and cataractous human lenses

4-(2-Aminophenyl)-4-oxobutanoic acid, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid and glutathionyl-kynurenine have been identified as novel metabolites in normal and cataractous human lenses following total synthesis and comparison with authentic human

N-(4-(PIPERAZIN-1-YL)-PHENYL-2-OXAZOLIDINONE-5-CARBOXAMIDE DERIVATES AND RELATED COMPOUNDS AS ANTIBACTERIAL AGENTS

The present invention provides antibacterial agents having the formula I described herein. or-pharmaceutically acceptable salts thereof wherein: A is a structure i, ii, iii, or iv,W is N(H)C(X)-R,. Het, or -Y HET, in which the Hot or Y HET is option