80937-24-2

Basic information

• Product Name: (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid
• Synonyms: (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid
• CAS NO: 80937-24-2
• Molecular Formula: C₁₀H₇NO₅
• Molecular Weight: 221.17
• Mol File: 80937-24-2.mol
• Article Data: 14

Chemical Properties

• Melting Point: 169 °C
• Boiling Point: 437.4°C at 760 mmHg
• Flash Point: 193.3°C
• Appearance: /
• Density: 1.435g/cm³
• Vapor Pressure: 2E-08mmHg at 25°C
• Refractive Index: 1.614
• PKA: 3.00±0.10(Predicted)
• CAS DataBase Reference: (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid(80937-24-2)
• EPA Substance Registry System: (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid(80937-24-2)

Safety Data

• Hazardous Substances Data: 80937-24-2(Hazardous Substances Data)

Usage

General Description

"(E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid" is a chemical compound with a molecular formula C10H7NO5. It is a yellow crystalline solid that is used in organic synthesis and research. (E)-4-(2-Nitrophenyl)-4-oxo-2-butenoic acid is a nitrophenyl derivative of an α,β-unsaturated ketone, and it contains a nitro group, a phenyl group, and a carboxylic acid group. It may be used as a precursor for the synthesis of various pharmaceuticals and other organic compounds. The compound is not known to have any specific commercial or industrial applications, and its primary use is in scientific research and development.

InChI:InChI=1/C10H7NO5/c12-9(5-6-10(13)14)7-3-1-2-4-8(7)11(15)16/h1-6H,(H,13,14)/b6-5+

Upstream product

• 141-82-2 malonic acid 
• 58950-89-3 (2-nitrophenyl)glyoxal 
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• 563-96-2 2,2-dihydroxyacetic acid 
• 298-12-4 Glyoxilic acid 

Downstream Products

• 35402-55-2 4-(2-aminophenyl)-4-oxobutanoic acid 
• 1056025-76-3 2-acetylsulfanyl-4-(2-nitrophenyl)-4-oxobutanoic acid 

Relevant articles and documents

Design, synthesis, and bioevaluation of a novel class of (E)-4-oxo-crotonamide derivatives as potent antituberculosis agents

A series of novel (E)-4-oxo-2-crotonamide derivatives were designed and synthesized to find potent antituberculosis agents. All the target compounds were evaluated for their in vitro activity against Mycobacterium tuberculosis H37Rv(MTB). Results reveal that 4-phenyl moiety at part A and short methyl group at part C were found to be favorable. Most of the derivatives displayed promising activity against MTB with MIC ranging from 0.125 to 4 μg/mL. Especially, compound IIIa16 was found to have the best activity with MIC of 0.125 μg/mL against MTB and with MIC in the range of 0.05–0.48 μg/mL against drug-resistant clinical MTB isolates.

First total synthesis of the antifungal antibiotic thiobutacin

The first total synthesis of thiobutacin, a butanoic acid with antifungal activity recently isolated from the culture broth of a soil actinomycete, Lechevalieria aerocolonigenes strain VK-A9, is described. The five-step procedure involves readily availabl

N-(4-(PIPERAZIN-1-YL)-PHENYL-2-OXAZOLIDINONE-5-CARBOXAMIDE DERIVATES AND RELATED COMPOUNDS AS ANTIBACTERIAL AGENTS

The present invention provides antibacterial agents having the formula I described herein. or-pharmaceutically acceptable salts thereof wherein: A is a structure i, ii, iii, or iv,W is N(H)C(X)-R,. Het, or -Y HET, in which the Hot or Y HET is option