80967-19-7

Downstream Products

• 27293-96-5 3,5-bis-(4-chloro-phenyl)-1-phenyl-1H-pyrazole 
• 30542-35-9 1,3,3-Tris-(4-chlor-phenyl)-prop-2-en-1-on 
• 98606-88-3 2-(4-Chloro-benzoyl)-3,3-bis-ethylsulfanyl-acrylonitrile 
• 98606-83-8 2-Bromo-1-(4-chloro-phenyl)-3,3-bis-ethylsulfanyl-propenone 

Relevant academic research and scientific papers

Indium(0)-mediated Csp 3-S/O cross-coupling approach towards the regioselective alkylation of α-enolic esters/dithioesters: A mechanistic Insight

We have reported an indium(0)-mediated Csp3-S/O cross-coupling approach that leads to the highly regioselective alkylation of α-enolic acetate/dithioacetate systems. This hetero cross-coupling reaction does not require additional co-catalyst or promoter, and the in situ generated organoindium species promotes the reaction by acting as the coupling partner of the α-enolic acetate/dithioacetate substrates. The excellent selectivity for C-, S-, or O-alkylation is solely dependent on the nucleophilic behavior of α-enolic acetate/dithioacetate systems. These results were further supported by DFT calculations of the relative electronic energies of the substrates and products as well as the activation barriers of the respective transformations.