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Usage

Uses

Used in Pharmaceutical Production:
DL-3-AMINO-3-(3-CYANO-PHENYL)-PROPIONIC ACID is utilized as an active pharmaceutical ingredient and a building block in the synthesis of various medications. Its unique structure allows it to be a key component in the development of drugs targeting neurological disorders and cancer treatment.
Used in Biochemical Research:
In the field of biochemical research, DL-3-AMINO-3-(3-CYANO-PHENYL)-PROPIONIC ACID is employed as a fluorescent probe. This application takes advantage of its properties to track and visualize biological processes, offering researchers a valuable tool for studying complex molecular interactions and mechanisms.
Used in Organic Synthesis:
As a chemical compound with a distinctive structure, DL-3-AMINO-3-(3-CYANO-PHENYL)-PROPIONIC ACID is also used in organic synthesis for the creation of new molecules and materials. Its versatility in chemical reactions makes it a valuable precursor in the synthesis of a wide range of organic compounds.

Upstream product

• 141-82-2 malonic acid 
• 24964-64-5 3-Cyanobenzaldehyde 

Downstream Products

• 167886-90-0 3-phthalimido-3-(3-cyanophenyl)propionic acid 
• 80972-14-1 N-[1-(3-Cyano-phenyl)-3-morpholin-4-yl-3-oxo-propyl]-4-methyl-benzenesulfonamide 
• 80972-60-7 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-benzamidine; hydriodide 
• 80972-59-4 3-[1-(Naphthalene-2-sulfonylamino)-3-oxo-3-piperidin-1-yl-propyl]-benzamidine; hydriodide 
• 80972-56-1 3-[3-Morpholin-4-yl-3-oxo-1-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide 
• 80972-58-3 3-(3-Carbamimidoyl-phenyl)-N-phenyl-3-(toluene-4-sulfonylamino)-propionamide; hydriodide 
• 80972-55-0 3-[3-Oxo-3-piperidin-1-yl-1-(toluene-4-sulfonylamino)-propyl]-benzamidine; hydriodide 
• 80972-57-2 N-Butyl-3-(3-carbamimidoyl-phenyl)-3-(toluene-4-sulfonylamino)-propionamide; hydriodide 
• 80972-46-9 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzimidic acid methyl ester; hydriodide 
• 80972-42-5 3-[3-Morpholin-4-yl-3-oxo-1-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide 
• 80972-44-7 3-[2-Phenylcarbamoyl-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 
• 80972-41-4 3-[3-Oxo-3-piperidin-1-yl-1-(toluene-4-sulfonylamino)-propyl]-thiobenzimidic acid methyl ester; hydriodide 
• 80972-43-6 3-[2-Butylcarbamoyl-1-(toluene-4-sulfonylamino)-ethyl]-thiobenzimidic acid methyl ester; hydriodide 
• 80972-32-3 3-[3-Morpholin-4-yl-1-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide 

Relevant academic research and scientific papers

Iridium-catalysed C-H borylation of β-aryl-aminopropionic acids

Iridium-catalysed catalytic, regioselective C-H borylation of β-aryl-aminopropionic acid derivatives gives access to 3,5-functionalised protected β-aryl-aminopropionic acid boronates. The synthetic versatility of these new boronates is demonstrated through sequential one-pot functionalisation reactions to give diverse building blocks for medicinal chemistry. The C-H borylation is also effective for dipeptide substrates. We have exemplified this methodology in the synthesis of a pan αv integrin antagonist.

Structure activity relationships of αv integrin antagonists for pulmonary fibrosis by variation in aryl substituents

Antagonism of αvβ6 is emerging as a potential treatment of idiopathic pulmonary fibrosis based on strong target validation. Starting from an αvβ3 antagonist lead and through simple variation in the nature and position of the aryl substituent, the discovery of compounds with improved αvβ6 activity is described. The compounds also have physicochemical properties commensurate with oral bioavailability and are high quality starting points for a drug discovery program. Compounds 33S and 43E1 are pan αv antagonists having ca. 100 nM potency against αvβ3, αvβ5, αvβ6, and αvβ8 in cell adhesion assays. Detailed structure activity relationships with these integrins are described which also reveal substituents providing partial selectivity (defined as at least a 0.7 log difference in pIC50 values between the integrins in question) for αvβ3 and αvβ5.

Antithrombotic carboxylic acid amides

Carboxylic acid amides of formula having antithrombotic activity and a factor Xa-inhibiting activity. Exemplary are: 2-(5-amidino-2-hydroxy-phenyl)-N-[3-methyl-4-(2-tert-butoxycarbonylaminomethyl -benzimidazol-1-yl)-phenyl]-acetamide; 2-(5-amidino-2-hydro

Antithrombotic compounds

Antithrombotic compounds of general formula Exemplary are: (1) 2-(5-carbamimidoyl-2-hydroxy-phenyl)-N-[3-methyl-4-(pyrrolidin-1-yl-carbonyl)-phenyl]-ethylamine, (2) N-(5-carbamimidoyl-2-hydroxy-benzyl)-3-methyl-4-(pyrrolidin-1-yl-carbonyl)-benzylamine, and (3) N-(5-carbamimidoyl-2-hydroxy-benzyl)-2,5-dimethyl-4-(pyrrolidin-1-yl-carbonyl)-benzylamine.