80994-42-9

Basic information

• Product Name: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, ethyl ester, (S)-
• CAS NO: 80994-42-9
• Molecular Formula: C14H16N2O2
• Molecular Weight: 244.293
• Mol File: 80994-42-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, ethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, ethyl ester, (S)-(80994-42-9)
• EPA Substance Registry System: 1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, ethyl ester, (S)-(80994-42-9)

Safety Data

• Hazardous Substances Data: 80994-42-9(Hazardous Substances Data)

Usage

Derivative of pyridoindole-3-carboxylic acid

This compound is derived from pyridoindole-3-carboxylic acid, which is a tricyclic indole with a carboxylic acid group.

Ethyl ester

The compound is an ethyl ester, meaning it is formed from the reaction of ethanol with the carboxylic acid group of the molecule. This adds an ethoxy group (-OCH2CH3) to the molecule.

Tetrahydro group

The compound contains a tetrahydro group, which indicates the presence of four hydrogen atoms bonded to the carbon atoms in the ring structure. This adds additional complexity to the molecule and can affect its physical and chemical properties.

(S)configuration

The (S)designation indicates that the compound is in its stereochemically pure form, with all the substituents attached to the stereocenter in the S (sinister) configuration. This can affect the compound's interactions with other molecules and its biological activity.

Potential applications

1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, ethyl ester, (S)has potential applications in the pharmaceutical or chemical industries. Its specific properties and uses would depend on its intended application, such as a precursor for the synthesis of other compounds or as an active ingredient in a drug formulation.

Upstream product

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Relevant articles and documents

3-di-amine β- carboline base compound, preparation method and pharmaceutical composition and application thereof

The invention discloses a 3-position diamine connected beta-carboline alkali compound, and a preparation method, a medicinal composition and a use thereof. The above di-beta-carboline alkali compound and its medicinal salt are represented by general formu

Design, synthesis, and biological evaluation of novel N-acylhydrazone bond linked heterobivalent β-carbolines as potential anticancer agents

Utilizing a pharmacophore hybridization approach, we have designed and synthesized a novel series of 28 new heterobivalent β-carbolines. The in vitro cytotoxic potential of each compound was evaluated against the five cancer cell lines (LLC, BGC-823, CT-26, Bel-7402, and MCF-7) of different origin—murine and human, with the aim of determining the potency and selectivity of the compounds. Compound 8z showed antitumor activities with half-maximal inhibitory concentration (IC50) values of 9.9 ± 0.9, 8.6 ± 1.4, 6.2 ± 2.5, 9.9 ± 0.5, and 5.7 ± 1.2 μM against the tested five cancer cell lines. Moreover, the effect of compound 8z on the angiogenesis process was investigated using a chicken chorioallantoic membrane (CAM) in vivo model. At a concentration of 5 μM, compound 8z showed a positive effect on angiogenesis. The results of this study contribute to the further elucidation of the biological regulatory role of heterobivalent β-carbolines and provide helpful information on the development of vascular targeting antitumor drugs.

Design, synthesis, anti-TMV, fungicidal, and insecticidal activity evaluation of 1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid derivatives based on virus inhibitors of plant sources

By drawing the creation ideas of botanical pesticides, a series of tetrahydro-β-carboline-3-carboxylic acid derivatives were designed and synthesized, and first evaluated for their anti-TMV, fungicidal and insecticidal activities. Most of these derivatives exhibited good antiviral activity against TMV both in vitro and in vivo. Especially, the activities of compounds 8 and 15 in vivo were higher than that of ribavirin. The compound 8 exhibited more than 70% fungicidal activities against Cercospora arachidicola Hori, Alternaria solani, Bipolaris maydis, and Rhizoctonia solani at 50 mg/kg, compounds 16 and 20 exhibited more than 60% insecticidal activities against Mythimna separate and Ostrinia nubilalis.