81015-93-2Relevant academic research and scientific papers
CERTAIN ANTIHYPERTENSIVE 1-[2-[3-CARBAMOYL-4-HYDROXYPHENOXY]ALKYLENEAMINO]-HETEROCYCLIC PHENOXY-PROPANOL DERIVATIVES
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, (2008/06/13)
The invention relates to novel substituted phenyl ethers of the formula STR1 in which Ar represents a mono-or bi-cyclic carbocyclic aryl radical, or a mono-or bi-cyclic heterocyclic aryl radical bonded to a phenylene radical by way of a ring carbon atom,Ph represents a phenylene radical,n has the value 0 to 1 andalk represents alkylene having from 2 to 5 carbon atoms, the nitrogen atom and the oxygen atom or, if n is 0, the aromatic radical being separated from each other by at least two carbon atoms in the unbranched chain, andR 1 and R. sub.2 each represents, independently of the other, hydrogen or lower alkyl, or together represent lower alkylene, oxa-lower alkylene, thia-lower alkylene, aza-lower alkylene or N-lower alkyl-aza-lower alkylene, and salts thereof, especially pharmaceutically acceptable non-toxic acid addition salts. Such compounds possess, on the one hand, blocking properties towards β-adrenergic receptors and can therefore be used as β-receptor-blockers with or without cardioselectivity for the treatment of Angina pectoris, hypertrophic cardiomyopathy and heart rhythm disorders and also as blood-pressure-reducing agents. On the other hand, such compounds possess β-receptor-stimulating properties and can therefore be used as positively inotropically active agents, especially as cardiotonics, for the treatment of heart muscle insufficiency.
