81017-23-4

Upstream product

• 779-27-1 7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid 
• 108-24-7 acetic anhydride 

Downstream Products

• 919350-85-9 Acetic acid (2R,3S,4S,5R,6S)-3,5-diacetoxy-2-acetoxymethyl-6-{4-[2-[4-(7-acetoxy-2-oxo-2H-chromene-3-carbonyl)-piperazin-1-yl]-1-(4-nitro-phenoxycarbonyloxy)-2-oxo-ethyl]-phenoxy}-tetrahydro-pyran-4-yl ester 
• 919350-80-4 acetic acid 4,5-diacetoxy-2-acetoxymethyl-6-(4-{2-[4-(7-acetoxy-2-oxo-2H-chromene-3-carbonyl)piperazin-1-yl]-1-hydroxy-2-oxoethyl}phenoxy)tetrahydropyran-3-yl ester 
• 919350-83-7 Acetic acid (2S,3R,4S,5S,6R)-4,5-diacetoxy-6-acetoxymethyl-2-(4-{2-[4-(7-acetoxy-2-oxo-2H-chromene-3-carbonyl)-piperazin-1-yl]-1-fluoro-2-oxo-ethyl}-phenoxy)-tetrahydro-pyran-3-yl ester 

Relevant academic research and scientific papers

Design and synthesis of an enzyme activity-based labeling molecule with fluorescence spectral change

Methods of covalent labeling of a specific tag protein with small-molecular dyes play an important role in studying dynamic behaviors of proteins in living cells. On the basis of quinone methide chemistry, we designed and synthesized a β-galactosidase labeling probe, CMFβ-gal, which shows a fluorescence wavelength change accompanying the labeling reaction, owing to fluorescence resonance energy transfer (FRET). Since the FRET efficiency changes accompanying the labeling reaction, fluorescence of labeled protein can be observed separately from that of the unreacted probe, so immediate detection of the target protein is possible. This is the first report of a protein labeling probe which features a change of fluorescence wavelength upon reaction, allowing the labeled protein to be detected even in the presence of unreacted probe. Copyright

Syntheses and Spectral Properties of Longwave Absorbing and Fluorescing Substrates for the Direct and Continuous Kinetic Assay of Carboxylesterases, Phosphatases, and Sulfatases

Syntheses, absorption and fluorescence properties for a series of new enzyme substrates are described, which are derived from 7-hydroxycoumarins possessing electron-withdrawing substituents in position 3.The new substrates are advantageous over existing ones in that they exhibit longwave absorption and fluorescence maxima as well as large Stokes' shifts.In addition, their pKa values, which are usually between 6.0 and 7.0, allow the direct and continuous kinetic assay of hydrolases such as esterases, phosphatases, and sulfatases. - Keywords: Enzyme substrates; Absorption spectra; Fluorescence spectra

Novel penicillin derivatives containing a coumarin nucleus and medicines containing the same

This invention provides novel penicillin derivatives of formula [I]; STR1 wherein A is hydrogen or hydroxyl, and B represents the cumarin nucleus of formula [III-a]; STR2 in which B1, B2, B3, B4 and B5/sub