81020-79-3

Usage

Uses

Used in Organic Synthesis:
[(5-methylfuran-2-yl)methylidene]propanedinitrile is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows for the creation of a wide range of molecules with different properties and applications.
Used in Materials Science:
In the field of materials science, [(5-methylfuran-2-yl)methylidene]propanedinitrile may be utilized as a building block for the development of novel materials with specific characteristics. Its chemical properties could contribute to the creation of materials with enhanced performance in areas such as electronics, energy storage, or advanced coatings.
Used in Pharmaceutical Research:
Given its unique chemical structure, [(5-methylfuran-2-yl)methylidene]propanedinitrile may also hold potential in the pharmaceutical industry. It could be investigated for its possible role in the development of new drugs or drug delivery systems, particularly in the context of its interactions with biological targets.
Used in Chemical Research:
As a furan derivative with a distinct structure, [(5-methylfuran-2-yl)methylidene]propanedinitrile may be valuable in academic and industrial research settings. It could be employed as a subject of study to better understand the properties and reactivity of similar compounds, potentially leading to new discoveries and innovations in the field of chemistry.

Upstream product

• 117778-31-1 3-[(5-methyl-2-furyl)methylene]pentane-2,4-dione 
• 109-77-3 malononitrile 
• 620-02-0 5-Methylfurfural 

Downstream Products

• 129027-86-7 5-Acetyl-2-amino-6-methyl-4-(5-methyl-furan-2-yl)-4H-pyran-3-carbonitrile 
• 1221564-31-3 4-[2-amino-3-cyano-4-(5-methyl-2-furyl)-5-oxo-5,6,7,8-tetrahydroquinolin-1(4H)-yl]benzenesulfonamide 
• 1203810-12-1 2-amino-7,7-dimethyl-4-(5-methyl-furan-2-yl)-5-oxo-1-(3,4,5-trimethoxyphenyl)-1,4,5,6,7,8-hexahydroquinoline-3-carbonitrile 
• 312531-32-1 2-amino-6,7,8,9-tetrahydro-4-(5-methylfuran-2-yl)-5H-cyclohepta[b]pyridine-3-carbonitrile 

Relevant academic research and scientific papers

Photoredox-Catalyzed Addition of Carbamoyl Radicals to Olefins: A 1,4-Dihydropyridine Approach

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.

Synthesis and anticholinesterase activity of novel non-hepatotoxic naphthyridine-11-amine derivatives

Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenz

New facile, eco-friendly and rapid synthesis of trisubstituted alkenes using bismuth nitrate as lewis acid

Background: For the synthesis of tri and tetra-substituted alkenes, Knoevenagel condensations have previously been performed in solvents like dichloromethane, DMF, toluene, acetonitrile, DMSO etc. These conditions suffer from certain limitations like long

Structural simplification of bioactive natural products with multicomponent synthesis. 4. 4H-Pyrano-[2,3-b]naphthoquinones with anticancer activity

4H-Pyrano-[2,3-b]naphthoquinone is a structural motif commonly found in natural products manifesting anticancer activities. As part of a program aimed at structural simplification of bioactive natural products utilizing multicomponent synthetic processes,

Synthesis and evaluation of a series of aminocyanopyridines as antimicrobial agents

With the aim of developing potential antimicrobials, a series of 2-amino-3-cyanopyridines incorporating both sulfur and oxygen as part of the heteroaromatic ring (methyl thiophene, methyl furan) and fused cycloalkane groups were synthesized and characterized by FTIR, 1H-NMR, 13C-NMR, and bases of elemental analysis. All synthesized compounds were evaluated for their in vitro antibacterial and antifungal activity. Antibacterial and antifungal activities of aminocyanopyridines against Pseudomonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium (clinical isolate), the gram-positive bacterium Micrococcus luteus NRRLB 4375, and the fungus Candida albicans ATCC 90028 were studied. The relationship between the functional-group variation and the biological activity of the evaluated compounds is discussed. Birkhaeuser Boston 2010.

2-Amino-6-furan-2-yl-4-substituted nicotinonitriles as A2a adenosine receptor antagonists

A2A adenosine receptor antagonists usually have bi- or tricyclic N aromatic systems with varying substitution patterns to achieve desired receptor affinity and selectivity. Using a pharmacophore model designed by overlap of nonxanthine type of previously known A2A antagonists, we synthesized a new class of compounds having a 2-amino nicotinonitrile core moiety. From our data, we conclude that the presence of at least one furan group rather than phenyl is beneficial for high affinity on the A2A adenosine receptor. Compounds 39 (LUF6050) and 44 (LUF6080) of the series had Ki values of 1.4 and 1.0 nM, respectively, with reasonable selectivity toward the other adenosine receptor subtypes, A1, A 2B, and A3. The high affinity of 44 was corroborated in a cAMP second messenger assay, yielding subnanomolar potency for this compound.

SYNTHESIS AND REACTIONS OF 5-ACETYL-2-AMINO-3-CYANO-4-(5-X-2-FURYL)-6-METHYL-4H-PYRANS

Substituted 2-amino-4-(5-X-2-furyl)-4H-pyrans IIIa - IIIe have been prepared by a cyclization reaction of 5-X-2-furylmethylenepropanedinitriles IIa-IIe with 2,4-pentanedione.In reaction of 3-(5-X-2-furyl)methylene-2,4-pentanediones Ia-Ie with propanedinit