81033-28-5

Upstream product

• 52313-43-6 3-acetyl-1-phenyl-pentane-1,4-dione 
• 133216-64-5 4-acetyl-3-methyl-6,6-diphenyl-1,2-dioxan-3-ol 
• 7803-49-8 hydroxylamine 
• 81022-96-0 3,5-dimethyl-4-phenylethynylisoxazole 

Relevant academic research and scientific papers

Syntheses of 4-(2-hydroperoxy-2,2-diarylethyl)-3,5-dimethylpyrazoles, 4-(2-hydroxy-2,2-diarylethyl)-3,5-dimethylpyrazoles and the related compounds

The reactions of 1,1-disubstituted ethenes with 2,4-pentanedione in the presence of manganese(III) acetate and atmospheric oxygen yielded 4-acetyl-6,6-diaryl-3-methyl-1,2-dioxan-3-ols. The latter gave 4-(2-hydroperoxy-2,2-diarylethyl)-3,5-dimethylpyrazoles by the reaction with hydrazines in methanol-acetic acid (1:1 v/v) at 50° in 15-77% yields, or 4-(2-hydroxy-2,2-diarylethyl)-3,5-dimethylpyrazoles by the reaction with hydrazines in methanol in 2-78% yields. The acid-catalyzed reaction of 4-(2-hydroperoxy-2,2-diarylethyl)-3,5-dimethylpyrazoles yielded 4-(aroylmethyl)-3,5-dimethylpyrazoles (15-55%) and 4-(2,2-diarylethenyl)-3,5-dimethylpyrazoles (9-29%).

HYDRATION AND HYDROGENATION OF ACETYLENIC SIDE-CHAINS AT THE 4- OR 5-POSITION OF ISOXAZOLES

Hydration of 5-isoxazolyl-phenyl(or -butyl)acetylenes (1a, b) in dilute sulfuric acid in the presence of mercuric sulfate afforded 5-isoxazolylmethyl phenyl (or butyl) ketones (3a, b), predominantly.In contrast, the hydration of 4-isoxazolyl-phenyl(or -bu