81038-79-1Relevant academic research and scientific papers
Synthesis of furyl-, furylvinyl-, thienyl-, pyrrolinylquinazolines and isoindolo[2,1-a]quinazolines
Zaytsev,Revutskaya,Ku?menko,Novikov,Zubkov,Sorokina,Nikitina,Toze,Varlamov
, p. 1345 - 1353 (2016/03/08)
A method for the synthesis of hydrogenated furyl-, furylvinyl-, thienyl-, and pyrrolinyl-substituted quinazolin-4-ones was developed. A possibility of the reaction of 2-furylquinazolines with maleic anhydride was demonstrated. A number of quinazolines obtained were subjected to a primary bioscreening on inhibition of acetylcholinesterase.
Copper-Catalyzed Intramolecular C-C Bond Cleavage to Construct 2-Substituted Quinazolinones
Hu, Ben-Quan,Wang, Li-Xia,Yang, Luo,Xiang, Jun-Feng,Tang, Ya-Lin
supporting information, p. 4504 - 4509 (2015/07/27)
An efficient method for a copper-catalyzed intramolecular C-C bond cleavage to construct 2-substituted quinazolinones has been developed. The C-C bond at the 2-position of 2,2-disubstituted-1,2,3,4-tetrahydroquinazolinone was selectively cleaved by a Cu/air catalytic system. The trend for the cleavage was dependent on the leaving group in the order of: alkyl > methyl > phenyl > substituted aryl. The process described herein provides an explanation for the mechanism of the reaction between substituted 2-halobenzamides and α-substituted arylmethanamines to construct 2-substituted quinazolinones, which were previously reported and limited to the construction of 2-arylquinazolinones. The C-C bond at the 2-position of 2,2-disubstituted-1,2,3,4-tetrahydroquinazolinones was selectively cleaved by a Cu/air catalytic system to construct 2-substituted quinazolinones. The trend for the cleavage of the C-C bond was dependent on the leaving group in the order of: alkyl > methyl > phenyl > substituted aryl.
