81039-83-0

Upstream product

• 83450-55-9 [(S)-1-((S)-1-{(S)-1-[(R)-1-[(S)-1-((S)-1-Carbamoyl-3-methylsulfanyl-propylcarbamoyl)-3-methyl-butylcarbamoyl]-2-(1H-indol-3-yl)-ethylcarbamoyl]-2-phenyl-ethylcarbamoyl}-2-phenyl-ethylcarbamoyl)-4-guanidino-butyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis and Biological Activities of Substance P Antagonists

Several substance P analogues containing various D-amino acid modifications have been synthesized by the solid-phase procedure, detached from the solid support by ammonolysis, and purified by gel filtration combined with reversed-phase chromatography.Three compounds were fair to very potent competitive antagonists of substance P on three bioassays, i.e., guinea pig ileum, rabbit mesenteric vein, and guinea pig trachea. 6,D-Trp10>SP(6,11) is a reasonable antagonist in all three bioassays and 4,D-Trp7,9>SP(4-11) is a very potent competitive antagonist with pA2 values ranging around 6.0.