810662-38-5 Usage
Uses
Used in Pharmaceutical Synthesis:
2-bromo-1-(4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone is utilized as a key intermediate in the synthesis of pharmaceuticals, contributing to the development of drugs that can effectively target specific biological pathways. Its unique structure allows for the creation of compounds with potential therapeutic applications.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, 2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone is employed in research aimed at understanding and manipulating biological processes. It aids in the discovery and optimization of new drug candidates, enhancing the potential for innovative treatments.
Used in Chemical and Material Manufacturing:
Beyond its pharmaceutical applications, 2-bromo-1-(4-(4-methyl-1H-imidazol-1-yl)phenyl)ethanone is also used in the manufacturing process of various chemicals and materials, highlighting its versatility in different industries.
Used in Research and Development:
2-bromo-1-(4-(4-methyl-1Himidazol-1-yl)phenyl)ethanone is integral to research and development efforts, where it is used to explore new chemical reactions, synthesize novel compounds, and advance scientific knowledge in organic chemistry and related fields.
Check Digit Verification of cas no
The CAS Registry Mumber 810662-38-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,0,6,6 and 2 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 810662-38:
(8*8)+(7*1)+(6*0)+(5*6)+(4*6)+(3*2)+(2*3)+(1*8)=145
145 % 10 = 5
So 810662-38-5 is a valid CAS Registry Number.
810662-38-5Relevant academic research and scientific papers
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators
Barnes, Keith D.,Buckle, Ronald N.,Chen, Xinchao,Herr, R. Jason,Johnson, Graham,Lin, Juinn H.,Mayhew, Nicholas J.,Mobley, William C.,Nguyen, Phuong,Paquette, William D.,Rynearson, Kevin D.,Sakwa, Samuel A.,Tanzi, Rudolph E.,Wagner, Steven L.,Yang, Jinhai
, (2020/09/22)
The evolution of gamma-secretase modulators (GSMs) through the introduction of novel heterocycles with the goal of aligning activity for reducing the levels of Aβ42 and properties consistent with a drug-like molecule are described. The insertion of a methoxypyridine motif within the tetracyclic scaffold provided compounds with improved activity for arresting Aβ42 production as well as improved properties, including solubility. In vivo pharmacokinetic analysis demonstrated that several compounds within the novel series were capable of crossing the BBB and accessing the therapeutic target. Treatment with methoxypyridine-derived compound 64 reduced Aβ42 levels in the plasma of J20 mice, in addition to reducing Aβ42 levels in the plasma and brain of Tg2576 mice.
COMPOUDS AND USES THEREOF IN MODULATING AMYLOID BETA
-
, (2015/11/16)
Novel compounds, compositions, and kits are provided. Methods of modulating Aβ levels, and methods of treating a disease associated with aberrant Aβ levels are also provided.
