810666-57-0Relevant articles and documents
A Selective Sulfide Oxidation Catalyzed by Heterogeneous Artificial Metalloenzymes Iron?NikA
Cavazza, Christine,Lopez, Sarah,Ménage, Stéphane,Marchi-Delapierre, Caroline
, p. 16633 - 16638 (2020/11/30)
Performing a heterogeneous catalysis with proteins is still a challenge. Herein, we demonstrate the importance of cross-linked crystals for sulfoxide oxidation by an artificial enzyme. The biohybrid consists of the insertion of an iron complex into a NikA protein crystal. The heterogeneous catalysts displays a better efficiency-with higher reaction kinetics, a better stability and expand the substrate scope compared to its solution counterpart. Designing crystalline artificial enzymes represents a good alternative to soluble or supported enzymes for the future of synthetic biology.