810673-96-2

Basic information

• Product Name: H-Hyp(Bzl)-OFm
• CAS NO: 810673-96-2
• Molecular Weight: 399.489
• Mol File: 810673-96-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: H-Hyp(Bzl)-OFm(CAS DataBase Reference)
• NIST Chemistry Reference: H-Hyp(Bzl)-OFm(810673-96-2)
• EPA Substance Registry System: H-Hyp(Bzl)-OFm(810673-96-2)

Safety Data

• Hazardous Substances Data: 810673-96-2(Hazardous Substances Data)

Upstream product

• 40350-83-2 (2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid 
• 24324-17-2 9-Fluorenylmethanol 

Downstream Products

• 47747-76-2 Boc-Pro-Hyp(Bzl)-Gly-OH 
• 810673-99-5 Boc-Pro-Hyp(Bzl)-Gly-OMe 
• 810673-98-4 Boc-Pro-Hyp(Bzl)-OH 

Relevant articles and documents

Intact glycation end products containing carboxymethyl-lysine and glyoxal lysine dimer obtained from synthetic collagen model peptide

Glycation reactions using a model peptide of collagen and glucose or ribose resulted in detection of carboxylmethyl-lysine in the peptide; and treatment with glyoxal provided a dimer of the peptide linked with glyoxal lysine dimer (GOLD). Advanced glycation end products (AGE) are accumulated in human tissues when long-lived proteins are glycated due to hyperglycemia and/or aging. In this study, we synthesized a collagen model peptide, Ac-(Pro-Hyp-Gly) 5-Pro-Lys-Gly-(Pro-Hyp-Gly)5-Ala-NH2 to investigate intact AGEs in peptides. The peptide formed a stable triple helix structure, and was subjected to glycation reactions with glucose, ribose and glyoxal. Besides carboxymethyl-lysine in the peptide, a conjugated form linked with glyoxal lysine dimer (GOLD) was detected upon treatment with glyoxal. This is the first example of intact glycation-derived dimers of peptides retaining intrinsic protein structures.