Mal-PEG1-t-butyl ester is a PEG-based linker that features a maleimide group and a t-butyl ester group. The hydrophilic PEG spacer enhances solubility in aqueous environments, while the t-butyl protected carboxyl group can be deprotected under acidic conditions. The maleimide group is capable of reacting with thiol groups to form covalent bonds, allowing for the attachment of biomolecules with thiol groups.
810677-16-8
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Basic information
- Product Name: Mal-PEG1-t-butyl ester
- Synonyms: Mal-PEG1-t-butyl ester
- CAS NO:810677-16-8
- Molecular Formula: C13H19NO5
- Molecular Weight: 269.29366
- EINECS: N/A
- Product Categories: N/A
- Mol File: 810677-16-8.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: Soluble in DMSO, DCM, DMF
- CAS DataBase Reference: Mal-PEG1-t-butyl ester(CAS DataBase Reference)
- NIST Chemistry Reference: Mal-PEG1-t-butyl ester(810677-16-8)
- EPA Substance Registry System: Mal-PEG1-t-butyl ester(810677-16-8)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 810677-16-8(Hazardous Substances Data)
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810677-16-8 Usage
Uses
Used in Bioconjugation:Mal-PEG1-t-butyl ester is used as a bioconjugation agent for the attachment of biomolecules with thiol groups. The maleimide group reacts with thiol groups to form stable covalent bonds, facilitating the linkage of proteins, peptides, or other biomolecules to the PEG spacer.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Mal-PEG1-t-butyl ester is used as a component in drug delivery systems. The PEG spacer can improve the solubility and stability of drug molecules, while the t-butyl protected carboxyl group allows for controlled release under specific conditions.
Used in Diagnostic Imaging:
In the field of diagnostic imaging, Mal-PEG1-t-butyl ester is used as a contrast agent enhancer. The PEG spacer can improve the solubility and circulation time of imaging agents, while the maleimide group can be used to attach imaging agents with thiol groups, such as fluorescent dyes or radionuclides.
Used in Tissue Engineering:
In tissue engineering, Mal-PEG1-t-butyl ester is used as a component in hydrogels and scaffolds. The PEG spacer can improve the biocompatibility and water retention of these materials, while the maleimide group can be used to attach bioactive molecules, such as growth factors or extracellular matrix proteins, to promote tissue regeneration and healing.
Check Digit Verification of cas no
The CAS Registry Mumber 810677-16-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,0,6,7 and 7 respectively; the second part has 2 digits, 1 and 6 respectively.Calculate Digit Verification of CAS Registry Number 810677-16:
(8*8)+(7*1)+(6*0)+(5*6)+(4*7)+(3*7)+(2*1)+(1*6)=158
158 % 10 = 8
So 810677-16-8 is a valid CAS Registry Number.
810677-16-8Upstream product
810677-16-8Downstream Products
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Mal-PEG1-t-butyl ester
