810681-06-2Relevant academic research and scientific papers
Design and Optimization of 3′-(Imidazo[1,2- a]pyrazin-3-yl)-[1,1′-biphenyl]-3-carboxamides as Selective DDR1 Inhibitors
Mo, Cheng,Zhang, Zhang,Li, Yupeng,Huang, Minhao,Zou, Jian,Luo, Jinfeng,Tu, Zheng-Chao,Xu, Yong,Ren, Xiaomei,Ding, Ke,Lu, Xiaoyun
supporting information, p. 379 - 384 (2020/01/31)
DDR1 is considered as a promising target for cancer therapy, and selective inhibitors against DDR1 over other kinases may be considered as promising therapeutic agents. Herein, we have identified a series of 3′-(imidazo[1,2-a]pyrazin-3-yl)-[1,1′-biphenyl]
Potent and Highly Selective Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors Act as Chemotherapeutic Potentiators in Acute Myeloid Leukemia and T-Cell Acute Lymphoblastic Leukemia
Verma, Kshitij,Zang, Tianzhu,Penning, Trevor M.,Trippier, Paul C.
supporting information, p. 3590 - 3616 (2019/04/26)
Aldo-keto reductase 1C3 (AKR1C3) catalyzes the synthesis of 9α,11β-prostaglandin (PG) F2α and PGF2α prostanoids that sustain the growth of myeloid precursors in the bone marrow. The enzyme is overexpressed in acute myeloid leukemia (
NEAR-IR GLUCOSE SENSORS
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Paragraph 0487; 0488, (2018/07/15)
Glucose-sensing luminescent dyes, polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.
HIGHLY SELECTIVE AKR1C3 INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 120, (2018/09/08)
The present invention includes methods and compositions that inhibit AKR1C3 enzymatic activity and consequently reduces androgen receptor (AR) transactivation, AR and prostate specific antigen (PSA) expression levels in, for example, prostate cancer, cast
Triazine derivatives linked with fused cyclic phenanthridinyl group, and organic electroluminescent device including the same
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Paragraph 0125-0129, (2017/10/25)
Provided are a triazine derivative bound with a fused cyclic phenanthridine group by a linker, represented by chemical formula 1, and an organic electroluminescent device comprising the same. In the chemical formula 1, Ar_1 and Ar_2 are each independently
Phosphoryl substituted triazine derivatives and organic electroluminescent device including the same
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Paragraph 0096-0098, (2017/01/02)
The present invention relates to phosphoryl group bonded triazine derivatives represented by chemical formulas 1 and 2. In the chemical formulas 1 and 2, the definitions of the substituent groups are the same as defined in the specification. The triazine derivative has excellent current density and durability in comparison to a conventional material. The organic electroluminescent device has a lowered driving voltage, improved luminous efficiency, and extended lifespan.COPYRIGHT KIPO 2016
Phosphoryl substituted triazine derivatives and organic electroluminescent device including the same
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Paragraph 0109-0111, (2017/01/26)
The present invention relates to phosphoryl group bonded triazine derivatives represented by chemical formulas 1 and 2. In the chemical formulas 1 and 2, the definitions of the substituent groups are the same as defined in the specification. The triazine derivatives have excellent current density and durability in comparison to a conventional material. The organic electroluminescent device has reduced driving voltage, improved luminous efficiency, and extended lifespan.COPYRIGHT KIPO 2016
A tetrameric cage with D2h symmetry through alkyne metathesis
Wang, Qi,Zhang, Chenxi,Noll, Bruce C.,Long, Hai,Jin, Yinghua,Zhang, Wei
supporting information, p. 10663 - 10667 (2015/05/13)
Shape-persistent covalent organic polyhedrons (COPs) with ethynylene linkers are usually prepared through kinetically controlled cross-coupling reactions. The high-yielding synthesis of ethynylene-linked rigid tetrameric cages via one-step alkyne metathes
Dipeptide Mimics, Libraries Combining Two Dipeptide Mimics with a Third Group, and Methods for Production Thereof
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Page/Page column 36, (2012/09/22)
Monovalent compounds having moieties comprising at least one amino acid side chain are bound to a core molecule, which also comprises a nucleophilic moiety bound to said core molecule. Monovalent compounds also comprise a macrocyclic ring, a nucleophilic
Universal peptidomimetics
Ko, Eunhwa,Liu, Jing,Perez, Lisa M.,Lu, Genliang,Schaefer, Amber,Burgess, Kevin
supporting information; experimental part, p. 462 - 477 (2011/04/16)
This paper concerns peptidomimetic scaffolds that can present side chains in conformations resembling those of amino acids in secondary structures without incurring excessive entropic or enthalpic penalties. Compounds of this type are referred to here as minimalist mimics. The core hypothesis of this paper is that small sets of such scaffolds can be designed to analogue local pairs of amino acids (including noncontiguous ones) in any secondary structure; i.e., they are universal peptidomimetics. To illustrate this concept, we designed a set of four peptidomimetic scaffolds. Libraries based on them were made bearing side chains corresponding to many of the protein-derived amino acids. Modeling experiments were performed to give an indication of kinetic and thermodynamic accessibilities of conformations that can mimic secondary structures. Together, peptidomimetics based on these four scaffolds can adopt conformations that resemble almost any combination of local amino acid side chains in any secondary structure. Universal peptidomimetics of this kind are likely to be most useful in the design of libraries for high-throughput screening against diverse targets. Consequently, data arising from submission of these molecules to the NIH Molecular Libraries Small Molecule Repository (MLSMR) are outlined.
