810682-85-0Relevant academic research and scientific papers
Multinuclear platinum(II)-amine complexes containing bis(aminopropyl) dicarba-closo-dodecaborane(12) ligands
Woodhouse, Susan L.,Rendina, Louis M.
, p. 3669 - 3677 (2004)
Treatment of the bridging bidentate 1,Z-bis(aminopropyl)-1,Z-dicarba-closo- dodecaborane(12) (1,Z-bis(aminopropyl)-1,Z-carborane) ligands of the type 1,Z-{H2N(CH2)3}2-1,Z-C 2B10H10 (L1, Z = 7, 5) or (L 2, Z = 12, 6) with two equivalents of trans-[PtClI 2(NH3)]-, followed by halogen ligand metathesis with AgOTf and HCl(aq) afforded the novel diplatinum(II)-amine species cis-[{PtCl2(NH3)}2Ln] (7 (n = 1) or 8 (n = 2), respectively). Similarly, the reaction of L1 or L2 with the labile trans-[PtCl(dmf)(NH3)2] + afforded trans-[{PtCl(NH3)2} 2Ln](OTf)2 (9 (n = 1) or 10 (n = 2), respectively) in good yield and purity. However, isolation of the analogous 1,2-carborane complexes was not possible owing to decomposition reactions that led to extensive degradation of the carborane cage and reduction of the metal centre. The mixed dinuclear complex [cis-{PtCl2(NH 3)}-L1-trans-{PtCl(NH3)2}]OTf (19) was prepared by treatment of the Boc-protected amine ligand 1-{(Boc) 2N(CH2)3}-7-{H2N(CH 2)3}-1,7-C2B10H10 (L 3,15) with trans-[PtCl(dmf)(NH3)2]+ to yield trans-[PtCl(NH3)2L3]OTf (16), followed by acid deprotection of the pendant amine group, complexation with trans-[PtClI2(NH3)]-, and halogen ligand metathesis using AgOTf and HCl(aq). A novel trinuclear species containing 5 was prepared by the addition of two equivalents of 15 to the labile precursor cis-[Pt(dmf)2(NH3)2]2+ followed by acid deprotection of the pendant amine groups. Further complexation with two equivalents of trans-[PtClI2(NH3)]- followed by halogen ligand metathesis using AgOTf and HCl(aq) afforded the triplatinum(II)-amine species [cis-{Pt(NH3) 2(L1)2}-cis-{PtCl2(NH 3)}2](OTf)2 (23). Complexes 7-10, 19 and 23 represent the first examples of multinuclear platinum(II)-amine derivatives containing carborane cages. Preliminary in vitro cytotoxicity studies for selected complexes are also reported.
