810694-79-2Relevant academic research and scientific papers
Synthesis of 2′,3′-dideoxyinosine via radical deoxygenation
Torii, Takayoshi,Izawa, Kunisuke,Cho, Dae Hyan,Jang, Doo Ok
, p. 985 - 988 (2008/03/28)
A synthetic method for 2′,3′-dideoxyinosine (ddI) from inosine was established via radical deoxygenation of N1,5′-O-diprotected-2′, 3′-bis-S-methyl dithiocarbonate of inosine derivatives. The radical deoxygenation proceeded smoothly to give the desired dideoxy compounds in good yields using 1-ethylpiperidinium hypophosphite and triethylborane. Benzyl or p-methoxybenzyl protection of inosine at the N1, 5′-O-positions were effective for the ddI synthesis. Copyright Taylor & Francis Group, LLC.
INOSINE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME
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Page/Page column 11, (2010/11/08)
The present invention provides a method for producing an inosine derivative represented by the following general formula (1) including the steps of subjecting an inosine derivative of general formula (3) to dithiocarbonylation and carrying out radical reduction of the obtained compound. According to the present invention there can be produced compounds useful as anti-AIDS drugs on industrial scale. wherein R1 may be the same or different and are each benzyl group, benzhydryl group or trityl group, each of which may have a substituent in general formulas (1) and (3).
