810694-83-8Relevant academic research and scientific papers
Synthesis of 2′,3′-dideoxyinosine via radical deoxygenation
Torii, Takayoshi,Izawa, Kunisuke,Cho, Dae Hyan,Jang, Doo Ok
, p. 985 - 988 (2007)
A synthetic method for 2′,3′-dideoxyinosine (ddI) from inosine was established via radical deoxygenation of N1,5′-O-diprotected-2′, 3′-bis-S-methyl dithiocarbonate of inosine derivatives. The radical deoxygenation proceeded smoothly to give the desired dideoxy compounds in good yields using 1-ethylpiperidinium hypophosphite and triethylborane. Benzyl or p-methoxybenzyl protection of inosine at the N1, 5′-O-positions were effective for the ddI synthesis. Copyright Taylor & Francis Group, LLC.
