81088-96-2

Upstream product

• 31166-44-6 phenylmethyl 1-piperazinecarboxylate 
• 107-04-0 1-Bromo-2-chloroethane 

Downstream Products

• 104740-55-8 4-(2-aminoethyl)-1-piperazinecarboxylic acid phenylmethyl ester 
• 636602-67-0 4-(2-ureidoethyl)piperazine-1-carboxylic acid benzyl ester 
• 636602-68-1 1-[2-(1-benzyloxycarbonylpiperazin-4-yl)-ethyl]-6-methyl-1H,3H-pyrimidin-2,4-dione 
• 1357575-57-5 benzyl 4-(2-(di-tert-butoxyphosphoryloxy)ethyl)piperazine-1-carboxylate 
• 1357575-59-7 (R)-di-tert-butyl 2-(4-(4-(phenylthio)-3-(4-sulfamoyl-2-(trifluoromethylsulfonyl)phenylamino)butyl)piperazin-1-yl)ethyl phosphate 
• 1357575-60-0 di-tert-butyl 2-(4-((R)-3-(4-(N-(4-(4-((R)-(tert-butyldimethylsilyloxy)(4'-chlorobiphenyl-2-yl)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperazin-1-yl)ethyl phosphate 
• 1357576-66-9 2-(4-((R)-3-(4-(N-(4-(4-((R)-(4'-chlorobiphenyl-2-yl)(hydroxy)methyl)piperidin-1-yl)benzoyl)sulfamoyl)-2-(trifluoromethylsulfonyl)phenylamino)-4-(phenylthio)butyl)piperazin-1-yl)ethyl dihydrogen phosphate 

Relevant academic research and scientific papers

Synthesis of 1-substituted-6-methyluracils.

A series of 6-methyl-1H-pyrimidin-2,4-diones bearing different substituents in the 1-position of the uracil ring were prepared starting from substituted ureas and diketene.

CHEMICAL COMPOUNDS

The present invention relates to compounds of Formula (I): and to their salts, pharmaceutical compositions, methods of use, and methods for their preparation. These compounds inhibit Bcl-2 and/or Bcl-XL activities and may be used for the treatment of cancer.