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3-A-Hydroxy Pravastatin Sodium Salt is a bioactive metabolite of both Pravastatin and Mevastatin. It functions as a competitive inhibitor of HMG-CoA reductase, an enzyme that plays a crucial role in cholesterol synthesis. 3-A-HYDROXY PRAVASTATIN SODIUM SALT has gained attention for its potential therapeutic applications in managing cholesterol levels and cardiovascular health.
Used in Pharmaceutical Industry:
3-A-Hydroxy Pravastatin Sodium Salt is used as a cholesterol-lowering agent for its ability to inhibit HMG-CoA reductase, the key enzyme in cholesterol biosynthesis. This action leads to a reduction in low-density lipoprotein (LDL) cholesterol levels, which is beneficial in preventing and treating conditions associated with high cholesterol, such as atherosclerosis and coronary heart disease.
Additionally, as a metabolite of Mevastatin, 3-A-Hydroxy Pravastatin Sodium Salt may also contribute to the overall therapeutic effects of Mevastatin, which is another drug used for lowering cholesterol levels. Its presence in Mevastatin formulations could potentially enhance the drug's efficacy and provide additional cardiovascular benefits.

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Basic information
1. Product Name: 3-A-HYDROXY PRAVASTATIN SODIUM SALT
2. Synonyms: 3-A-HYDROXY PRAVASTATIN SODIUM SALT;3-a-iso-Pravastatin;3-α-iso-Pravastatin;3--Hydroxy Pravastatin Lactone;3--Hydroxy Pravastatin Sodium Salt;Pravastatin Related Compound A (15 mg) (Sodium (3R,5R)-3,5-dihydroxy-7-[(1S,2S,3S,8S,8aR)-3-hydroxy-2-methyl-8-[[(2S)-2-methylbutanoyl]oxy]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] heptanoate);(βR,δR,1S,2R,3S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-β,δ,3-trihydroxy-2-Methyl-8-[(2S)-2-Methyl-1-oxobutoxy]-1-naphthaleneheptanoic Acid SodiuM Salt;[1S-[1α(βS*,δS*),2α,3α,8β(R*),8aα]]-1,2,3,7,8,8a-Hexahydro-β,δ,3-trihydroxy-2-Methyl-8-(2-Methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid
3. CAS NO:81093-43-8
4. Molecular Formula: C23H35NaO7
5. Molecular Weight: 446.51
6. EINECS: N/A
7. Product Categories: Various Metabolites and Impurities;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Chiral Reagents
Chemical Properties
1. Melting Point: 54-56°C
2. Boiling Point: N/A
3. Flash Point: N/A
4. Appearance: /
5. Density: N/A
6. Refractive Index: N/A
7. Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
8. Solubility: Methanol (Slightly), Water (Slightly)
9. Stability: Hygroscopic
10. CAS DataBase Reference: 3-A-HYDROXY PRAVASTATIN SODIUM SALT(CAS DataBase Reference)
11. NIST Chemistry Reference: 3-A-HYDROXY PRAVASTATIN SODIUM SALT(81093-43-8)
12. EPA Substance Registry System: 3-A-HYDROXY PRAVASTATIN SODIUM SALT(81093-43-8)
Safety Data
1. Hazard Codes: N/A
2. Statements: N/A
3. Safety Statements: N/A
4. WGK Germany:
5. RTECS:
6. HazardClass: N/A
7. PackingGroup: N/A
8. Hazardous Substances Data: 81093-43-8(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 81093-43-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,0,9 and 3 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 81093-43:
(7*8)+(6*1)+(5*0)+(4*9)+(3*3)+(2*4)+(1*3)=118
118 % 10 = 8
So 81093-43-8 is a valid CAS Registry Number.

81093-43-8 Well-known Company Product Price

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(Code)Product description
CAS number
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USP
(1554217) Pravastatin Related Compound A United States Pharmacopeia (USP) Reference Standard
81093-43-8
1554217-10MG
14,578.20CNY
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81093-43-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name	sodium,(3R,5R)-7-[(1S,2R,3S,8S,8aR)-3-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate

1.2 Other means of identification

Product number	-
Other names	3alpha-Hydroxy Pravastatin Sodium Salt

1.3 Recommended use of the chemical and restrictions on use

Identified uses	For industry use only.
Uses advised against	no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number	-
Service hours	Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

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