81097-46-3

Upstream product

• 81097-48-5 N-tosyl-6-azabicyclo[3.1.0]hexane 
• 70-55-3 toluene-4-sulfonamide 
• 142-29-0 cyclopentene 

Downstream Products

• 81097-30-5 trans-1-N-tosyl-2-(3-butenyl)cyclopentylamine 
• 81097-28-1 trans-1-N-tosyl-2-(2-propenyl)cyclopentylamine 

Relevant academic research and scientific papers

Highly efficient regioselective ring openings of N-tosylaziridines to haloamines using ferric (III) halides

FeX3 (X = Cl, Br) were found to be very effective reagents and powerful catalysts for regioselective ring openings of a variety of N-tosylaziridines with them to afford the corresponding β-haloamines in good to excellent yields with high regios

PPh3/halogenating agent-mediated highly efficient ring opening of activated and non-activated aziridines

We report here the use of PPh3/halogenating agents as highly efficient reagents for the ring opening of aziridines with halides. The method works effectively for both activated and non-activated aziridines, and furnishes the products in excelle

New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3

A series of cyclopentane derivatives was synthesized and evaluated for inhibition of the steroid metabolizing enzymes AKR1C1 and AKR1C3. Selective inhibitors that are active in the low micromolar range were identified. These compounds represent promising starting points in the development of new anticancer agents for the treatment of hormone-dependent forms of cancer and other diseases where AKR1C1 and AKR1C3 are involved.

FeCl2-catalyzed aminobromination of alkenes using amides or sulfonamides and NBS as the nitrogen and bromine sources

We have developed a convenient and efficient iron-catalyzed aminobromination of the alkenes using inexpensive FeCl2 as the catalyst, amides/sulfonamides and NBS as the nitrogen and bromine sources, respectively, under mild conditions.

Highly regioselective ring opening of epoxides and aziridines using (bromodimethyl)sulfonium bromide

Epoxides and aziridines undergo ring opening efficiently with (bromodimethyl)sulfonium bromide at room temperature to form the corresponding β-bromohydrins and β-bromoamines, respectively. The conversions are highly regioselective and afford the products in excellent yields within a short period of time.

Regioselective ring opening of aziridines with activated DMF complexes: A facile synthesis of β-haloamines

A wide variety of aziridines were converted to the corresponding β-haloamines using activated DMF complexes in good to excellent yields with high regioselectivity.

A facile regioselective ring opening of aziridines to haloamines using tetrabutylammonium halides in the presence of β-cyclodextrin in water

A variety of N-tosylaziridines undergo regioselective ring opening with tetrabutylammonium halides in the presence of β-cyclodextrin in water at pH 4 and room temperature to afford the corresponding haloamines in excellent yields.

Highly Efficient Regioselective Ring Opening of Aziridines to β-Haloamines in the Presence of β-Cyclodextrin in Water

Aziridines are opened regioselectively with hydrogen and lithium halides to yield β-haloamines in the presence of β-cyclodextrin using water as the solvent.

Indium trihalide mediated regioselective ring opening of aziridines: A facile synthesis of 2-haloamines

A variety of N-tosyl aziridines undergo ring opening with indium trihalides in acetonitrile at ambient temperature to afford the corresponding haloamines in excellent yields with high regioselectivity.