81110-73-8 Usage
Description
Different sources of media describe the Description of 81110-73-8 differently. You can refer to the following data:
1. Racecadotril (also called acetorphan) is a kind of antidiarrheal drug acting as a peripherally acting enkephalinase inhibitor. It has an antisecretory effect, reducing the secretion of water and electrolytes into the intestine. Racecadotril is a protodrug, being broken down into the active ingredient, thiorphan. Thiorphan exerts its inhibitory effect on enkephalinase, reducing the amount of secreted water produced by the intestines. In this case, the body loses less fluid, and the symptoms of diarrhea can be alleviated.
2. Acetorphan is an orally-active enkephalinase inhibitor introduced in 1993 for the
treatment of acute diarrhea in adults.It displays antidiarrheal activity via a purely
antisecretory mechanism without inhibiting intestinal transit. Acetorphan acts as rapidly as
loperamide, a classical mu opiate receptor agonist that exhibits its antidiarrheal effect via an
antitransit mechanism, without producing constipation or other side effects. The novel
mechanism of action may render acetorphan potentially useful in the management of
infectious diarrhea.
3. Racecadotril is an enkephalinase inhibitor that prevents the degradation of endogenous opioids. It demonstrates antidiarrheal activity by reducing hypersecretion of water and electrolytes into the intestinal lumen. Racecadotril is a pro-drug that is metabolized in vivo into the active compound, thiorphan .
References
https://en.wikipedia.org/wiki/Racecadotril
https://patient.info/medicine/racecadotril-for-acute-diarrhoea-hidrasec
Chemical Properties
White Solid
Originator
Bioprojet (France)
Uses
Antidiarrheal; enkephalinase inhibitor, reducing the amount of water and electrolytes into the intestine.
Brand name
Tiorfan
Clinical Use
Treatment of acute diarrhoea
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
Quickly metabolised by hydrolysis to active metabolite,
thiorphan. Racecadotril is eliminated as active and
inactive metabolites. Elimination is mainly via the renal
route, and to a much lesser extent via the faecal route
(around 8%). The pulmonary route is not significant (less
than 1% of the dose).
Check Digit Verification of cas no
The CAS Registry Mumber 81110-73-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,1,1 and 0 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 81110-73:
(7*8)+(6*1)+(5*1)+(4*1)+(3*0)+(2*7)+(1*3)=88
88 % 10 = 8
So 81110-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H21NO5S/c22-18(26-13-16-9-5-2-6-10-16)12-21-19(23)17(14-27-20(24)25)11-15-7-3-1-4-8-15/h1-10,17H,11-14H2,(H,21,23)(H,24,25)
81110-73-8Relevant articles and documents
Enantioseparation of racecadotril using polysaccharide-type chiral stationary phases in polar organic mode
Szabó, Zoltán-István,Foroughbakhshfasaei, Mohammadhassan,Noszál, Béla,Tóth, Gerg?
, p. 95 - 105 (2018)
Enantioseparation of the antidiarrheal drug, racecadotril, was investigated by liquid chromatography using polysaccharide-type chiral stationary phases in polar organic mode. The enantiodiscrimininating properties of 4 different chiral columns (Chiralpak
A by 3 - phenyl -1 - methylacetylene preparation quickly disintegrating process method (by machine translation)
-
, (2019/07/10)
A by 3 - phenyl - 1 - propyne preparation quickly disintegrating process method, which belongs to the technical field of pharmaceutical intermediates. In the preparation quickly disintegrating in the process, intermediate benzyl acrylic acid yield and purity of the most important, this method first using 3 - phenyl - 1 - propyne as the raw material, in the palladium catalyst Pd2 (Dba)3 And the ligand dppp with ethyl carbonate under the catalysis of the reaction to the one-step synthesis of benzyl acrylic acid, its advantage lies in atmospheric pressure to complete the addition reaction, functional group tolerance is good, high efficiency, high purity, the production process is greatly simplified, and to obtain the target product preparation process of yield and purity than the traditional process much higher. The method has the advantages of greatly improve the productivity, reduce the cost, improve the safety, energy saving and the like, in accordance with the green reaction of modern chemical production requirement. (by machine translation)
Preparation method and detection method for ecadotril
-
, (2018/03/26)
The invention provides a preparation method and detection method for ecadotril. 2-benzyl-3-hydroxypropionic acid is used as a raw material, and a four-step method is employed for preparing an intermediate and ecadotril, so more options are provided for acquisition of the bulk drug ecadotril. At the same time, based on the fact that (R)-phenylethylamine has slightly different abilities in elution of ecadotril and ecadotril enantiomers, a liquid-phase detection method for racecadotril in European Pharmacopoeia is employed for separation and detection in a liquid-phase system of an achiral column. The detection method is simple to operate and easy to implement.
