81114-06-9Relevant academic research and scientific papers
IODINE-INDUCED IMINOTHIOLACTONIZATION OF γ,δ-UNSATURATED SECONDARY THIOAMIDES, NEW ENTRY TO 2-ACETOAMIDOTHIOPHENES
Takahata, Hiroki,Suzuki, Toshiaki,Maruyama, Mihoko,Moriyama, Keiko,Mozumi, Mayumi,et.al.
, p. 4777 - 4786 (2007/10/02)
Iodine-induced cyclization of γ,δ-unsaturated secondary thioamides 1 proceeded regio- (5-exo-trigonal) and chemo- (sulfur-carbon bond formation)selectively, providing iminothiolactones 2, which were converted in two-step sequences (dehydroiodination and N-acetylation) into 2-acetoamidothiophenes 4.This procedure was performed in one flask to afford polysubstituted 2-aminothiophenes.
THE REGIOSELECTIVE SC AND SN ALLYLIC REARRANGEMENT OF S-ALLYLTHIOIMIDATE
Tamaru, Y.,Kagotani, M.,Yoshida, Z.
, p. 4245 - 4248 (2007/10/02)
The radioselective SC and SN allylic rearrangements of S-allylthioimidates are realized by thermolysis (160-200 deg C) or palladium (II) catalysis (1-10 molpercent in refluxing THF), respectively.
