81114-38-7Relevant academic research and scientific papers
Allenes. Part 40. 2:1 Bis-adducts from Allenic Nitriles and Phenylpropynenitriles with Difunctional Nucleophiles and their Conversion into Heterocycles
Landor, Stephen R.,Landor, Phyllis D.,Fomum, Z. Tanee,Mbafor, J. Tanyi,Nkengfack, A. Ephraim
, p. 1223 - 1228 (2007/10/02)
Two equivalents of allenic nitrile or phenylpropynenitrile add to 1,2- and 1,3-diamines, 2-aminoethanethiol, ethanedithiol, and 4-aminopyridine to give 2:1 adducts of structure (2), (4), and (5).Ring closure and elimination of one equivalent each of allenic nitrile (or phenylpropynenitrile) and acetonitrile gave the imidazolines (29), the thiazolines (30), and the tetrahydropyrimidines (31).Mass spectral fission patterns are discussed.
Allenes. Part 39. The Synthesis of 3-Alkyl-5-aminopyrazoles and 3H-Indoles from Allenic or Acetylenic Nitriles
Fomum, Z. Tanee,Landor, Stephen R.,Landor, Phyllis D.,Mpango, George W. P.
, p. 2997 - 3001 (2007/10/02)
Hydrazine adds to allenic or acetylenic nitriles to give 3-alkyl-substituted 5-aminopyrazoles in excellent yields.Conjugated and unconjugated enaminic nitriles may be isolated from the Michael addition of phenylhydrazine to allenic nitriles and ring-close
