81118-92-5

Usage

General Description

2-METHOXY-5-NITROBENZENESULFONYL CHLORIDE, also known as MeONBSCl, is an organic compound with the chemical formula C7H6ClNO5S. It is a yellow solid that is soluble in organic solvents and reacts violently with water. 2-METHOXY-5-NITROBENZENESULFONYL CHLORIDE is commonly used as a reagent in organic synthesis for the introduction of the 2-methoxy-5-nitrobenzenesulfonyl (MeONBS) group onto other molecules. MeONBSCl is also used in the production of pharmaceuticals and dyes, as well as in research laboratories for the synthesis of various organic compounds. It is important to handle 2-METHOXY-5-NITROBENZENESULFONYL CHLORIDE with care, as it is a strong irritant and can cause severe burns to the skin, eyes, and respiratory system if not handled properly.

InChI:InChI=1/C7H6ClNO5S/c1-14-6-3-2-5(9(10)11)4-7(6)15(8,12)13/h2-4H,1H3

Upstream product

• 100-17-4 para-methoxynitrobenzene 

Downstream Products

• 100724-66-1 2-methoxy-5-nitro-benzenesulfonic acid anilide 
• 81514-23-0 2-Methoxy-5-nitro-N-[2-(4-sulfamoyl-phenyl)-ethyl]-benzenesulfonamide 
• 81514-28-5 C₁₉H₂₄N₄O₈S₂ 
• 81514-29-6 C₂₀H₂₆N₄O₈S₂ 
• 81514-30-9 C₂₂H₂₈N₄O₈S₂ 
• 1191410-45-3 1,1-dimethylethyl (3R)-3-({[2-(methyloxy)-5-nitrophenyl]sulfonyl}amino)-1-pyrrolidinecarboxylate 
• 1101118-56-2 N'-((5-cyanopyrazolo[1,5-a]pyridin-3-yl)methylene)-2-methoxy-N-methyl-5-nitrobenzenesulfonohydrazide 

Relevant academic research and scientific papers

BENZENESULFONAMIDE DERIVATIVES AS TRAP1 MODULATORS AND USES THEREOF

The present disclosure provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled compounds, and prodrugs thereof. The provided compounds may be tumor necrosis factor ("TNF") receptor associated protein 1 ("TRAP1") modulators (e.g., TRAP1 activators). The provided compounds may also rescue the activity in PTEN-induced kinase 1 ("PINK1") loss of function contexts. The provided compounds may also improve mitochondrial health, function, quality, quantity, and/or activity, and/or reduce the production of reactive oxygen species. The provided compounds may also refold or solubilize aggregated or misfolded proteins such as α-synuclein. The present disclosure also provides pharmaceutical compositions comprising the provided compounds; kits comprising the provided compounds or pharmaceutical compositions; and methods of using the provided compounds and pharmaceutical compositions (e.g., for treating a disease in a subject in need thereof).

BENZENESULFONAMIDE UPREGULATORS OF NPC1 FOR NEIMANN-PICK DISEASE AND OTHER LYSOSOMAL STORAGE DISORDERS

Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is s

BISSULFONAMIDE COMPOUNDS AS AGONISTS OF GALR1, COMPOSITIONS, AND METHODS OF USE

Embodiments of the present invention provide bissulfonamide compounds that are agonists of GalR1. The present invention further provides compositions comprising bissulfonamide compounds that are agonists of GalR1, and methods of use of such compounds and compositions.