81133-63-3Relevant academic research and scientific papers
Synthesis of 4-alkoxyaryl β-D-glucopyranosides and their inhibitory effects on histamine release from rat peritoneal mast cells induced by concanavalin A
Wang,Furukawa,Nihro,Kakegawa,Matsumoto,Satoh
, p. 570 - 575 (1994)
The inhibitory effects of newly synthesized 4-alkoxyaryl β-D- glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4- decyloxy-2,3,6-trimethylphenyl β-D-glucopyranoside was the most potent inhibitor among the tested compounds.
Synthesis and anti lipid-peroxidation activity of hydroquinone monoalkyl ethers
Nihro,Furukawa,Sogawa,Wang,Miyataka,Matsumoto,Miki,Satoh
, p. 576 - 579 (2007/10/02)
A series of hydroquinone monoalkyl ethers was synthesized and evaluated for anti lipid-peroxidation activity in rat liver microsomes. 4-Hexyloxy- 2,3,6-trimethylphenol (9), having a low redox potential, as well as ascorbic acid exhibited the strongest anti lipid-peroxidation activity (IC50 = 4.2 x 10-7 M). Structure-activity relationship studies demonstrated that the inhibitory effect of hydroquinone monoalkyl ethers on lipid peroxidation was increased by the acquisition of an optimum hydrophobicity and decreased by an insufficient or excessive hydrophobicity.
