81136-42-7

Basic information

• Product Name: 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE
• Synonyms: 4-Chloro-6-ethylthieno[2,3-d]pyrimidine ,98%;4-Chloro-6-ethylthieno[2,3-d]pyrimidine;4-chloro-6-ethylthieno[2
• CAS NO: 81136-42-7
• Molecular Formula: C₈H₇ClN₂S
• Molecular Weight: 198.67
• Product Categories: CHIRAL CHEMICALS
• Mol File: 81136-42-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 311.1°Cat760mmHg
• Flash Point: 141.9°C
• Appearance: /
• Density: 1.377g/cm³
• Vapor Pressure: 0.00106mmHg at 25°C
• Refractive Index: 1.657
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE(81136-42-7)
• EPA Substance Registry System: 4-CHLORO-6-ETHYLTHIENO[2,3-D]PYRIMIDINE(81136-42-7)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 81136-42-7(Hazardous Substances Data)

Usage

Chemical Properties

Grey solid

Uses

4-Chloro-6-ethylthieno[2,3-d]pyrimidine is a useful intermediate for organic synthesis.

InChI:InChI=1/C8H7ClN2S/c1-2-5-3-6-7(9)10-4-11-8(6)12-5/h3-4H,2H2,1H3

Upstream product

• 18593-51-6 6-ethyl-3H-thieno[2,3-d]pyrimidin-4-one 
• 18593-51-6 4-oxo-(3H)-6-ethylthieno<2,3-d>pyrimidine 
• 4507-13-5 ethyl 2-amino-5-ethylthiophene-3-carboxylate 

Downstream Products

• 81136-43-8 4-(4-bromophenyl)amino-6-ethyl<2,3-d>pyrimidine 
• 81136-44-9 4-(4-iodophenyl)amino-6-ethyl<2,3-d>pyrimidine 
• 251992-54-8 6-ethyl-N-(phenylmethyl)thieno[2,3-d]pyrimidin-4-amine 
• 929445-96-5 C₁₄H₁₁ClFN₃S 
• 423736-67-8 C₁₅H₁₅N₃S 
• 423732-85-8 C₁₄H₁₂ClN₃S 
• 423735-09-5 C₁₅H₁₅N₃OS 
• 423733-48-6 C₁₄H₁₃N₃S 
• 710289-67-1 C₁₄H₁₂FN₃S 
• 313534-29-1 N-(6-ethylthieno[2,3-d]pyrimidin-4-yl)glycine 
• 1388892-17-8 2-([4-(dimethylamino)cyclohexyl]({6-ethylthieno[2,3-d]pyrimidin-4-yl})amino)ethan-1-ol 
• 842971-64-6 1-[6-ethylthieno[2,3-d]pyrimidin-4-yl]piperidine-4-carboxylic acid 
• 1388892-03-2 1-N-[6-ethylthieno[2,3-d]pyrimidin-4-yl]4-N-methylcyclohexane-1,4-diamine 
• 1388892-05-4 tert-butyl N-[4-([6-ethylthieno[2,3-d]pyrimidin-4-yl]amino)cyclohexyl]carbarnate 

Relevant articles and documents

Design and synthesis of novel protein kinase CK2 inhibitors on the base of 4-aminothieno[2,3-d]pyrimidines

An extension of our previous research work has resulted in a number of new ATP-competitive CK2 inhibitors that have been identified among 4-aminothieno[2,3-d]pyrimidine derivatives. The most active compounds obtained in the course of the research are 3-(5-p-tolyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5e (NHTP23, IC50 = 0.01 μM), 3-(5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5g (NHTP25, IC50 = 0.065 μM) and 3-(6-methyl-5-phenyl-thieno[2,3-d]pyrimidin-4-ylamino)-benzoic acid, 5n (NHTP33, IC50 = 0.008 μM). Structure-activity relationships of the tested 4-aminothieno[2,3-d]pyrimidine derivatives have been studied and their binding mode with ATP-acceptor site of CK2 has been proposed. A negative effect of intramolecular hydrogen bonding in the compounds' structure is discussed.

COMPOSITIONS AND METHODS FOR TREATMENT OF LEUKEMIA

The invention relates generally to effective treatment leukemia. In particular, the present invention provides compositions and methods to inhibit the interaction of menin with MLL and MLL-fusion oncoproteins, and well as systems and methods to screen for such compositions.

Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone-based inhibitors of Cyclin D1-CDK4: Synthesis, biological evaluation, and structure-activity relationships

The synthesis and evaluation of new analogues of thieno[2,3-d]pyrimidin-4-yl hydrazones are described. 2-Pyrdinecarboxaldehyde [6-(tert-butyl)thieno[2,3-d]pyrimidine-4-yl]hydrazone derivatives have been identified as cyclin-dependent kinase 4 (CDK4) inhibitors. The potency, selectivity profile, and structure-activity relationship of this series of compounds are discussed.