811442-63-4Relevant academic research and scientific papers
Microwave-mediated reactions of 3-aminomethylpyridines with acetylenedicarboxylates. A novel synthetic route to dihydronaphthyridines and naphthyridine-1-ones
Vvedensky, Vladimir Y.,Ivanov, Yury V.,Kysil, Volodymyr,Williams, Caroline,Tkachenko, Sergei,Kiselyov, Alexander,Khvat, Alexander V.,Ivachtchenko, Alexandre V.
, p. 3953 - 3956 (2005)
Reaction of 3-(1-alkylamino)pyridines with electron deficient acetylenes in the presence of acids yields 1,2-dihydro[2,7]naphthyridine-3,4- dialkyldicarboxylates 4 in 35-72% yield. Compounds 4 unsubstituted in position 1 can be easily oxidized with potassium permanganate into the respective naphthyridine-1-ones derivatives 5 in good yields.
