811450-26-7 Usage
Uses
Used in Pharmaceutical Industry:
5-Fluoropyrimidin-4-amine is used as a pharmaceutical intermediate for the development of antiviral and anticancer drugs. Its application is based on its capacity to inhibit thymidylate synthase, an enzyme essential for DNA synthesis, thereby disrupting the growth and replication of cancer cells and potentially combating viral infections.
Used in Cancer Treatment:
5-Fluoropyrimidin-4-amine is utilized as an anticancer agent, targeting the disruption of DNA synthesis in cancer cells by inhibiting thymidylate synthase. This action can lead to the suppression of tumor growth and may be effective against a range of cancer types.
Used in Drug Development:
In the field of drug development, 5-fluoropyrimidin-4-amine serves as a key compound in the creation of new therapeutic agents. Its unique ability to target and inhibit a critical enzyme in DNA synthesis positions it as a promising candidate for further research and potential incorporation into novel medications aimed at treating cancer and viral diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 811450-26-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,1,1,4,5 and 0 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 811450-26:
(8*8)+(7*1)+(6*1)+(5*4)+(4*5)+(3*0)+(2*2)+(1*6)=127
127 % 10 = 7
So 811450-26-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H4FN3/c5-3-1-7-2-8-4(3)6/h1-2H,(H2,6,7,8)
811450-26-7Relevant academic research and scientific papers
Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt
Dietz, Jule-Philipp,Lucas, Tobias,Opatz, Till
, p. 445 - 450 (2020/03/27)
A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.
Peptide deformylase inhibitors
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Page/Page column, (2014/12/09)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhibition of bacterial peptide deformylase (PDF) activity.
PEPTIDE DEFORMYLASE INHIBITORS
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Page/Page column, (2014/02/15)
The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity
