811450-26-7

Basic information

• Product Name: 5-fluoropyrimidin-4-amine
• Synonyms: 5-fluoropyrimidin-4-amine;5-Fluoro-pyrimidin-4-ylamine;4-Pyrimidinamine, 5-fluoro-;5-fluoropyrimidin-4-amine analogue
• CAS NO: 811450-26-7
• Molecular Formula: C4H4FN3
• Molecular Weight: 113.09
• Mol File: 811450-26-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 222.7 °C at 760 mmHg
• Flash Point: 88.5 °C
• Appearance: /
• Density: 1.372 g/cm³
• Vapor Pressure: 0.1mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-fluoropyrimidin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoropyrimidin-4-amine(811450-26-7)
• EPA Substance Registry System: 5-fluoropyrimidin-4-amine(811450-26-7)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 811450-26-7(Hazardous Substances Data)

Usage

General Description

5-Fluoropyrimidin-4-amine is a chemical compound that belongs to the class of fluoropyrimidines. It is a derivative of pyrimidine with a fluorine atom attached to the fifth carbon, and an amino group attached to the fourth carbon. 5-fluoropyrimidin-4-amine has been studied for its potential use in pharmaceuticals, particularly in the development of antiviral and anticancer drugs. It is known for its ability to inhibit the enzyme thymidylate synthase, which is important for the synthesis of DNA. This makes 5-fluoropyrimidin-4-amine a promising candidate for cancer treatment, as it can disrupt the growth and replication of cancer cells. Research on this compound continues to explore its potential applications in medicine and drug development.

InChI:InChI=1/C4H4FN3/c5-3-1-7-2-8-4(3)6/h1-2H,(H2,6,7,8)

Upstream product

• 3473-63-0 formamidine acetic acid 
• 6313-33-3 formamidine hydrochloride 
• 347418-42-2 2,4-dichloro-5-fluoropyrimidine 

Relevant articles and documents

Synthesis of 4-amino-5-fluoropyrimidines and 5-amino-4-fluoropyrazoles from a β-fluoroenolate salt

A synthesis of fluorinated pyrimidines under mild conditions from amidine hydrochlorides and the recently described potassium 2-cyano-2-fluoroethenolate was developed. A broad substrate scope was tested and mostly excellent yields were obtained. The synthesis of fluorinated aminopyrazoles from the same fluorinated precursor could be demonstrated but proceeded with lower efficiency.

PEPTIDE DEFORMYLASE INHIBITORS

The present invention relates to a compound of Formula (I): or a pharmaceutically acceptable salt thereof, corresponding pharmaceutical compositions, compound preparation and treatment methods directed to bacterial infections and inhi-bition of bacterial peptide deformylase (PDF) activity