811450-53-0Relevant academic research and scientific papers
Discovery and optimization of a novel series of potent mutant B-Raf V600E selective kinase inhibitors
Vasbinder, Melissa M.,Aquila, Brian,Augustin, Martin,Chen, Huawei,Cheung, Tony,Cook, Donald,Drew, Lisa,Fauber, Benjamin P.,Glossop, Steve,Grondine, Michael,Hennessy, Edward,Johannes, Jeffrey,Lee, Stephen,Lyne, Paul,M?rtl, Mario,Omer, Charles,Palakurthi, Sangeetha,Pontz, Timothy,Read, Jon,Sha, Li,Shen, Minhui,Steinbacher, Stefan,Wang, Haixia,Wu, Allan,Ye, Minwei
, p. 1996 - 2015 (2013/05/09)
B-Raf represents an attractive target for anticancer therapy and the development of small molecule B-Raf inhibitors has delivered new therapies for metastatic melanoma patients. We have discovered a novel class of small molecules that inhibit mutant B-Raf
Asymmetric synthesis of (+)-castanospermine through enol ether metathesis-hydroboration/oxidation
Ceccon, Julien,Danoun, Gregory,Greene, Andrew E.,Poisson, Jean-Franois
scheme or table, p. 2029 - 2031 (2009/09/04)
An asymmetric synthesis of (+)-castanospermine is presented in which enol ether metathesis-hydroboration/oxidation is used for stereoselective installation of the trans-trans hydroxyl groups on the piperidine ring of the alkaloid.
