811450-82-5

Basic information

• Product Name: 2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide
• Synonyms: 2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide;2-(2-Chloroethoxy)-4'-nitroacetanilide
• CAS NO: 811450-82-5
• Molecular Formula: C₁₀H₁₁ClN₂O₄
• Molecular Weight: 259
• Product Categories: Aromatics;Intermediates;Miscellaneous Reagents
• Mol File: 811450-82-5.mol

Chemical Properties

• Appearance: /
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: 2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide(811450-82-5)
• EPA Substance Registry System: 2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide(811450-82-5)

Safety Data

• Hazardous Substances Data: 811450-82-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide is used as a reagent for the synthesis of N-Arylmorpholinones, which are important intermediates in the development of pharmaceutical compounds. These N-Arylmorpholinones can be further modified and used in the creation of drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, 2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide is employed as a reagent to facilitate the synthesis of N-Arylmorpholinones. This allows researchers to explore the properties and potential applications of these compounds, contributing to the advancement of scientific knowledge in organic chemistry.
Used in Organic Synthesis:
2-(2-Chloroethoxy)-N-(4-nitrophenyl)acetaMide is used as a reagent in organic synthesis processes, enabling the production of N-Arylmorpholinones. These compounds can be further utilized in the synthesis of various organic molecules, expanding the scope of chemical applications and products.

Upstream product

• 39229-33-9 2-(2-chloroethoxy)acetyl chloride 
• 100-01-6 4-nitro-aniline 
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• 57253-40-4 5-chloro-2,3-dihydro-1,4-dioxin 
• 14869-41-1 (2-chloroethoxy)-acetic acid 

Downstream Products

• 697284-64-3 (R)-{3-methyl-1-[4-(3-oxo-morpholin-4-yl)-phenylcarbamoyl]-butyl}-carbamic acid tert-butyl ester 
• 769119-47-3 (R)-2-Amino-4-methyl-pentanoic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide 
• 749250-58-6 (R)-2-aminopentanoic acid [4-(3-oxo-morpholin-4-yl)-phenyl]-amide 

Relevant articles and documents

PROCESS FOR THE PREPARATION OF 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

The field of this invention relates to a novel process, suitable for industrial scale manufacture, for the preparation of 4-(4-aminophenyl)morpholin-3-one of Formula (I), the key intermediate of rivaroxaban according to the scheme. In the process 2-(2-chloroethoxy)ethanol of Formula (XI) is oxidized to 2-(2-chloroethoxy)- acetic acid with aqueous sodium- or calcium-hypochlorite and a catalyst. The 2-(2~ chloroethoxy)acetic acid of Formula (X) is reacted with 4-nitro-aniline of Formula (VII) with phenylboronic acid catalyst. Then the 2-(2-chloroetoxy)-N-(4-nitrophenyl)acetamide of Formula (IX) is transformed to 4-(4-nitrophenyl)morpholin-3-one of Formula (IV) in a ?one- pot" procedure. The 4-(4-nitrophenyl)morpholin-3-one of Formula (IV) is hydrogenated to get 4-(4-aminophenyl)morpholin-3-one of Formula (I).

A the advantage cuts down Sha Ban preparation method of the midbody and intermediate

The invention discloses a preparation method of a rivaroxaban intermediate and an intermediate. The invention discloses a preparation method of a compound represented by the formula 4. The preparation method comprises a step of making a compound 3 carry out a ring closing reaction, which is represented in the description, so as to obtain the compound 4. The invention also discloses a preparation method of a compound represented by the formula 3 and a preparation method of a compound represented by the formula 1. The invention also discloses a compound represented by the formula 3 and a compound represented by the formula 5. The preparation method has the advantages of easily-available and cheap raw materials, simple technology and post-treatment, easy purification of intermediate and end products, high total yield, and high purity, and is easy for being applied to industrial production.

METHOD FOR PRODUCTION OF N-ARYL MORPHOLINONES

The invention relates to a method for production of compounds of formula (I), where X has the meaning given in claim 1 and precursors for the same.

Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa

Neutral chlorothiophenecarboxamides bearing an amino acid and a substituted aniline were synthesized and investigated for their factor Xa inhibitory activity in vitro. From selected 2-methylphenyl morpholinones the solution properties were determined. The most soluble and active compounds were then investigated in different animal species to compare the pharmacokinetic parameters. This led to a potent, water soluble and orally bioavailable candidate for further development: EMD 495235.