811456-40-3Relevant articles and documents
The identification of β-hydroxy carboxylic acids as selective MMP-12 inhibitors
Holmes, Ian P.,Gaines, Simon,Watson, Steve P.,Lorthioir, Olivier,Walker, Adam,Baddeley, Suzanne J.,Herbert, Shane,Egan, Danielle,Convery, Maire A.,Singh, Onkar M.P.,Gross, Jeffrey W.,Strelow, John M.,Smith, Robert H.,Amour, Augustin J.,Brown, David,Martin, Stephen L.
scheme or table, p. 5760 - 5763 (2010/04/05)
A new class of selective MMP-12 inhibitors have been identified via high throughput screening. Crystallization with MMP-12 confirmed the mode of binding and allowed initial optimization to be carried out using classical structure based design.
MATRIX METALLOPROTEINASE INHIBITORS
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Page/Page column 25-26, (2008/06/13)
Compounds of Formula (I): Wherein: A represents bond, C1-6alkyl or CH=CH-C1-4alkyl; B represents bond, O, S, SO, SO2, CO, CR7R8, CO2R14, CONR14R15, N(COR14)(COR15), N(SO2R14)(COR15) or NR14R15; D represents bond, or C1-6alkyl; E represents substituted ary
MATRIX METALLOPROTEINASE INHIBITORS
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Page 25; 26, (2010/02/09)
Compounds of formula (1): Wherein: Q represents an optionally substituted 5- or 6-membered aryl or heteroaryl ring; X represents 0, S, NR5 or CR6 R7; Y represents CHOH, CHSH, NOR8, CNR8 or CNOR8
