81154-03-2Relevant academic research and scientific papers
Reactions of 5-Arylmethylene-4-oxo-2-thioxothiazolidines with Amines
Omar, M. T.,Sherif, F. A.
, p. 849 - 851 (2007/10/02)
Piperidine, morpholine and benzylamine react with 5-arylmethylene-4-oxo-2-thioxothiazolidines (I) to give the corresponding piperidine (IIa-d), morpholine (IIe-f) and benzylamine (IIg) salts which on treatment with ethanol undergo decomposition to give the respective 2-piperidino- and 2-morpholino-4-oxo-2-thiazolines (III), and 2-benzylimino-4-oxothiazolidine (IVa).However, decomposition of IIa-d in the presence of an equimolar amount of morpholine gives mixtures of 2-piperidino- and 2-morpholino-4-oxo-2-thiazolines (III).Furthermore, decomposition of IIe, c and d inthe presence of an excess of a primary amine affords exclusively the respective 2-substituted-imino-4-oxo-thiazolidines (IV).Cleavage of 5-arylmethylene-3-methyl-4-oxo-2-thioxothiazolidines (Va-b and e-g) with excess of piperidine affords 1-(N-methylthiocarbamyl)piperidine (VI).The structures of II, III, IV and VI are based on analytical and spectral data.
