81166-47-4 Usage
Uses
Used in Pharmaceutical Research:
R-(+)-DIOA is used as a potassium/chloride K+-Cltransport inhibitor for studying its effects on various biological processes. Its specific inhibition of the K+/Cl--cotransport system allows researchers to investigate the role of this transporter in different cell types and tissues.
Used in Ion Transport Studies:
R-(+)-DIOA is used as a research tool to study the effects of K+/Cl--cotransport inhibition on short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium. This helps researchers understand the role of ion transport in maintaining the balance of electrolytes and fluid in the inner ear.
Used in Drug Uptake Research:
R-(+)-DIOA is used as a K+-Cltransport inhibitor to study its effects on the uptake of grepafloxacin by THP-1 monocytes. This application helps researchers investigate the role of ion transport in the absorption and distribution of drugs within the body.
Additionally, R-(+)-DIOA is used to study its effects on the uptake of moxifloxacin by THP-1 monocytes, providing further insights into the influence of ion transport on drug uptake and efficacy in different cell types.
Biochem/physiol Actions
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl?)?co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
Check Digit Verification of cas no
The CAS Registry Mumber 81166-47-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,1,6 and 6 respectively; the second part has 2 digits, 4 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 81166-47:
(7*8)+(6*1)+(5*1)+(4*6)+(3*6)+(2*4)+(1*7)=124
124 % 10 = 4
So 81166-47-4 is a valid CAS Registry Number.
InChI:InChI=1/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1
81166-47-4Relevant academic research and scientific papers
Agents for the treatment of brain injury. 1. (Aryloxy)alkanoic acids
Cragoe Jr.,Gould,Woltersdorf Jr.,Ziegler,Bourke,Nelson,Kimelberg,Waldman,Popp,Sedransk
, p. 567 - 579 (2007/10/02)
Blunt and ischemic injuries of the brain have been shown to result in swelling that is predominantly limited to a single cell type, the astrocyte, within the complex cellular mosaic of cerebral gray matter. Evaluation of various diuretic (aryloxy)acetic a
