81167-32-0

Basic information

• Product Name: 2-(N-diphenylmethylene)amino-3-(1H-indol-3-yl)propionitrile
• CAS NO: 81167-32-0
• Molecular Weight: 349.435
• Mol File: 81167-32-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N-diphenylmethylene)amino-3-(1H-indol-3-yl)propionitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-diphenylmethylene)amino-3-(1H-indol-3-yl)propionitrile(81167-32-0)
• EPA Substance Registry System: 2-(N-diphenylmethylene)amino-3-(1H-indol-3-yl)propionitrile(81167-32-0)

Safety Data

• Hazardous Substances Data: 81167-32-0(Hazardous Substances Data)

Upstream product

• 87-52-5 3-(Dimethylaminomethyl)indole 
• 70591-20-7 N-(diphenylmethylene)aminoacetonitrile 

Downstream Products

• 156722-88-2 2-(N-diphenylmethylene)amino-3-<1-(p-tolylsulfonyl)indol-3-yl>propionitrile 
• 131861-10-4 5-amino-3-(2-methylpropyl)-6-<1-(p-tolylsulfonyl)indol-3-ylmethyl>pyrazin-2(1H)-one 4-oxide 
• 131827-16-2 N-<1-cyano-2-<1-(p-tolylsulfonyl)indol-3-yl>ethyl>-2-hydroxyimino-4-methylvaleramide 
• 156722-89-3 2-amino-3-<1-(p-tolylsulfonyl)indol-3-yl>propionitrile 

Relevant articles and documents

Synthesis of 2,5-Dioxygenated Pyrazine 4-Oxides: Total Synthesis of a New Inhibitor of Superoxide Anion Generation, OPC-15161

The total synthesis of OPC-15161 1, a new inhibitor of superoxide anion generation, is described in full.Three approaches, routes A-C, have been investigated focusing on the pivotal structure 2,5-dioxygenated pyrazine 4-oxide.Among them, route A led to the total synthesis of 1.That is, the key precursor, 5-hydroxypyrazin-2(1H)-one 4-oxide 7 has been prepared from tryptophan methyl ester 2 in three steps, and direct methylation of the 5-hydroxy group of 7 or three-step methylation via the 2-O-Boc derivative 10 afforded 1 in 9.9-10.6percent overall yields.