81168-16-3Relevant academic research and scientific papers
Application of the intramolecular yamamoto vinylogous aldol reaction to the synthesis of macrolides
Abramite, Joseph A.,Sammakia, Tarek
, p. 2103 - 2106 (2008/02/02)
An intramolecular version of the Yamamoto vinylogous aldol reaction, a method that employs the bulky Lewis acid ATPH to control the site of aldolization, is described. This macrocyclization process is effective for the construction of 10-, 12-, and 14-mem
Safety-catch linkers
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, (2008/06/13)
Safety-catch linkers and methods for use of safety-catch linkers in solid phase and combinatorial solid phase synthesis are provided. Safety-catch linkers covalently bonded to solid supports are also provided. The safety-catch linkers are stable to a wide variety of synthetic protocols so that substrates, such as amines, thiols and alcohols, are cleaved from the linkers under mild conditions. The safety-catch linkers are useful in solid phase synthesis and modification of natural products and other complex organic substrates.
Synthesis of 3,9b-Dihydro-5H-pyrroloisoindoles and 3,5,6,10b-Tetrahydropyrroloisoquinolines with 1,3-Dipolar Cycloaddition Reactions.
Anderson, Wayne K.,Kinder, Frederick R.
, p. 975 - 979 (2007/10/02)
The title classes of compounds have been prepared using a sequence of two ring-forming reactions.Initial 1,3-dipolar cycloaddition with an azomethine ylide gave N-acylated 3-pyrrolines which were further elaborated to the target compounds by a tandem deprotection/cyclization reaction.
