81187-93-1

Upstream product

• 114566-93-7 ethyl 4-bromo-3-(4-chlorophenyl)-2-butenoate 
• 99-91-2 para-chloroacetophenone 
• 81187-86-2 ethyl 3-(4-chlorophenyl)-2-butenoate 
• 81187-90-8 (Z)-4-Bromo-3-(4-chloro-phenyl)-but-2-enoic acid 
• 81187-89-5 (E)-3-(4-chlorophenyl)but-2-enoic acid 
• 21133-98-2 ethyl 3-(4-chlorophenyl)-3-hydroxybutanoate 
• 928215-97-8 4-(4-chlorophenyl)-2-oxo-2,5-dihydropyrrole-1-carboxylic acid tert-butyl ester 
• 81187-91-9 (Z)-4-amino-3-(4-chlorophenyl)but-2-enoic acid 

Downstream Products

• 22518-27-0 4-(4-chlorophenyl)pyrrolidin-2-one 
• 123632-35-9 (R)-(-)-4-(4-chlorophenyl)pyrrolidin-2-one 
• 1134-47-0 4-amino-3-(4-chlorophenyl)butanoic acid 

Relevant academic research and scientific papers

Dihydropyrrolones as bacterial quorum sensing inhibitors

Bacteria regulate their pathogenicity and biofilm formation through quorum sensing (QS), which is an intercellular communication system mediated by the binding of signaling molecules to QS receptors such as LasR. In this study, a range of dihydropyrrolone (DHP) analogues were synthesized via the lactone-lactam conversion of lactone intermediates. The synthesized compounds were tested for their ability to inhibit QS, biofilm formation and bacterial growth of Pseudomonas aeruginosa. The compounds were also docked into a LasR crystal structure to rationalize the observed structure-activity relationships. The most active compound identified in this study was compound 9i, which showed 63.1% QS inhibition of at 31.25 μM and 60% biofilm reduction at 250 μM with only moderate toxicity towards bacterial cell growth.

TAMBJAMINES AND B-RING FUNCTIONALIZED PRODIGININES

Embodiments of tambjamines and B-ring functionalized prodiginines are disclosed. Methods of synthesizing and using the disclosed compounds are also disclosed. Some embodiments of the disclosed compounds have antimalarial activity. Certain embodiments of t

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

Synthesis and antimalarial activity of 94 novel bipyrrole tambjamines (TAs) and a library of B-ring functionalized tripyrrole prodiginines (PGs) against a panel of Plasmodium falciparum strains are described. The activity and structure-activity relationsh

Short synthesis of 4-aryl-3-pyrrolin-2-ones

A three step, convergent synthesis of 4-aryl-3-pyrrolin-2-ones from a tetramic acid has been developed. The key transformation utilized a Suzuki-Miyaura cross-coupling reaction between a 4-tosyloxy-3-pyrrolin-2-one and an arylboronic acid. This work also