81190-89-8Relevant academic research and scientific papers
ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS
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Page/Page column 145, (2021/10/15)
Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).
4-substituted-5(3)-carbamoyl-3(5)-(2-deoxy-β-D- ribofuranosyl)pyrazoles. Application of palladium catalyzed glycal coupling methodology to the synthesis of pyrazofurin analogs
Erion, Mark D.,Rydzewski, Robert M.
, p. 315 - 337 (2007/10/03)
Analogs of the C-nucleoside pyrazofurin were prepared in 7-9 steps using a key Pd(0)-catalyzed coupling reaction between protected iodopyrazoles 6a and 6b and glycal 8 to form the glycosyl bond. Conditions for this reaction were improved from those previously described for related reactions in order to maximize product yields and eliminate the need for triphenylarsine.
