81198-14-3

Upstream product

• 50-00-0 formaldehyd 
• 366-77-8 4-(4-fluorophenyl)-4-oxopropionic acid 

Downstream Products

• 68415-27-0 6-(4-fluoro-phenyl)-5-methyl-2H-pyridazin-3-one 
• 127847-39-6 [3-(4-Fluoro-phenyl)-4,5-dihydro-1H-pyrazol-4-yl]-acetic acid; hydrochloride 
• 127991-66-6 [3-(4-Fluoro-phenyl)-1H-pyrazol-4-yl]-acetic acid; hydrobromide 
• 127847-32-9 [1-Acetyl-3-(4-fluoro-phenyl)-4,5-dihydro-1H-pyrazol-4-yl]-acetic acid 
• 148133-89-5 cis/trans-4-(4-Fluorphenylmethyl)-3-(4-methylpiperidinomethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid 
• 148133-92-0 trans-3-<4-(4-Chlorphenyl)-4-hydroxy-piperidinomethyl>-4-(4-fluorphenylmethyl)-4,5-dihydro-2(3H)-furanon-hydrochlorid 
• 148133-91-9 trans-4-(4-Fluorphenylmethyl)-3-<4-(2-oxo-1-benzimidazolinyl)-piperidinomethyl>-4,5-dihydro-2(3H)-furanon 
• 148903-20-2 4-(4-Fluorphenylmethyl)-3-methylen-4,5-dihydro-2(3H)-furanon 
• 110766-30-8 6-(4-Fluoro-phenyl)-5-hydroxymethyl-4,5-dihydro-2H-pyridazin-3-one 
• 81198-15-4 acido 3-(p.fluorobenzoil)-3-butenoico 

Relevant academic research and scientific papers

Lactones, XXIII: Synthesis and stereochemistry of 'γ-lactonized' butyrophenone-type neuroleptics

'γ-Lactonized' neuroleptics (1,2a-c) can be obtained by reaction of α-formyl, α-carboxy- and α-methylene-lactones 5-7a,b with amines 8a-c. 6a, 1a-c were cis/trans-mixtures with predominating cis-compounds, 6b, 2a cis/trans-mixtures with predominating tran