81216-14-0

Basic information

• Product Name: 1-Heptyne, 7-bromo-
• CAS NO: 81216-14-0
• Molecular Formula: C7H11Br
• Molecular Weight: 175.068
• Mol File: 81216-14-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-Heptyne, 7-bromo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Heptyne, 7-bromo-(81216-14-0)
• EPA Substance Registry System: 1-Heptyne, 7-bromo-(81216-14-0)

Safety Data

• Hazardous Substances Data: 81216-14-0(Hazardous Substances Data)

Usage

Family

Alkyne

Explanation

Alkyne is a type of organic compound characterized by the presence of a carbon-carbon triple bond (C≡C). 1-Heptyne, 7-bromois a member of this family.

Explanation

The triple bond is a covalent bond formed by the sharing of three electron pairs between two carbon atoms, which is a key feature of alkyne compounds.

Explanation

The bromine atom is attached to the 7th carbon atom in the carbon chain, which gives the compound its unique properties and reactivity.

Explanation

1-Heptyne, 7-bromois commonly used as a starting material in various organic synthesis reactions, particularly in the production of pharmaceuticals and agrochemicals.

Explanation

The compound's versatile nature allows it to participate in a wide range of chemical reactions, making it a valuable building block for the synthesis of complex organic molecules.

Explanation

1-Heptyne, 7-bromohas potential applications in materials science and the chemical industry, making it a compound of interest for further research and development.

Triple Bond

Between carbon atoms

Bromine Atom

At the 7th position

Starting Material

Organic synthesis reactions

Versatile Nature

Ability to undergo chemical transformations

Applications

Materials science and chemical industry

Upstream product

• 63478-76-2 1-hydroxy-6-heptyne 
• 87462-63-3 hept-6-yn-1-yl 4-methylbenzenesulfonate 
• 111-24-0 1,5-dibromo-pentane 
• 1066-26-8 sodium acetylide 

Downstream Products

• 1363333-68-9 C₂HF₃O₂*C₃₀H₄₇N₆O₉P 
• 1363333-65-6 C₃₀H₄₆FN₆O₈P 

Relevant articles and documents

EPIGENETIC PROFILING METHOD

A method for analyzing DNA comprises forming labelled DNA fragments by cleaving genomic DNA into DNA fragments, selectively functionalizing any non-methylated CpG sites present in the DNA with a linker comprising a hydrolysable moiety, and attaching a label to the linker. The method further comprises separating the labelled DNA fragments from any non-labelled DNA fragments, hydrolysing the hydrolysable moiety of the linker of the separated labelled DNA fragments so as to release the DNA fragments from the label, and sequencing the released DNA fragments.

Hydroaminoalkylation of Allenes

The first examples of early-transition-metal-catalyzed hydroaminoalkylation reactions of allenes are reported. Initial studies performed with secondary aminoallenes led to the identification of a suitable titanium catalyst and revealed that under the reaction conditions, the initially formed hydroaminoalkylation products undergo an unexpected titanium-catalyzed rearrangement to form the thermodynamically more stable allylamines. The assumption that this rearrangement involves a reactive allylic cation intermediate provides a simple explanation of the fact that no successful early-transition-metal-catalyzed hydroaminoalkylations of allenes have previously been reported. As a result of the generation of the corresponding cation, the titanium-catalyzed intermolecular hydroaminoalkylation of propa-1,2-diene unexpectedly gives an aminocyclopentane product formed by incorporation of two equivalents of propa-1,2-diene.

Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7

Histone lysine demethylases (KDMs) are of critical importance in the epigenetic regulation of gene expression, yet there are few selective, cell-permeable inhibitors or suitable tool compounds for these enzymes. We describe the discovery of a new class of inhibitor that is highly potent towards the histone lysine demethylases KDM2A/7A. A modular synthetic approach was used to explore the chemical space and accelerate the investigation of key structure–activity relationships, leading to the development of a small molecule with around 75-fold selectivity towards KDM2A/7A versus other KDMs, as well as cellular activity at low micromolar concentrations.