81234-25-5

Usage

General Description

1-Propanone, 1-phenyl-3-(1H-1,2,4-triazol-1-yl)-, also known as 1-Phenyl-1H-1,2,4-triazol-3-ylpropan-1-one, is a chemical compound with the molecular formula C11H10N2O. It is a synthetic organic compound containing a phenyl group and a triazole ring attached to a propanone backbone. This chemical is used in the production of pharmaceuticals and agrochemicals, and it exhibits antifungal and antiparasitic properties. It is important to handle this chemical with care due to its potential for toxic, irritant, and environmental hazards.

Upstream product

• 288-88-0 1,2,4-Triazole 
• 768-03-6 Phenyl vinyl ketone 
• 936-59-4 3-chloropropiophenone 

Downstream Products

• 875441-42-2 2-bromo-1-phenyl-3-[1,2,4]triazol-1-yl-propan-1-one 
• 1266209-54-4 1-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-1-ol 

Relevant academic research and scientific papers

Design and synthesis of 3-(azol-1-yl)phenylpropanes as microbicidal spermicides for prophylactic contraception

We designed a series of 25 3-(azol-1-yl)phenylpropanes which yielded 10 compounds (3, 4, 7, 8, 13, 14, 19, 21, 23, 26) that irreversibly immobilized 100% human sperm at 1% (w/v) concentration in 60 s; 12 compounds (8, 9, 15, 16, 19-21, 23-25, 27, 28) that showed potent microbicidal activity at 12.5-50 μg/mL against Trichomonas vaginalis; and 17 compounds (3-11, 13, 15, 19, 21, 23, 26, 28, 30) that exhibited potent anticandida activity with minimum inhibitory concentration (MIC) of 12.5-50 μg/mL. Almost all the compounds exhibited high level of safety towards normal vaginal flora (Lactobacillus) and human cervical (HeLa) cells in comparison to the marketed spermicide nonoxynol-9 (N-9). All the biological activities were evaluated in vitro. Two compounds (4, 8) with good safety profile exhibited multiple (spermicidal, antitrichomonas and anticandida) activities, warranting further lead optimization for furnishing a prophylactic vaginal contraceptive.

A novel method for the high-pressure-promoted, uncatalyzed aza-Michael reaction of nitrogen heterocycles with enones in water

A new green chemical method for the aza-Michael reaction of nitrogen heterocycles with enones in water as a solvent without the use of any catalysts under high-pressure conditions is described. Georg Thieme Verlag Stuttgart.