81234-31-3Relevant academic research and scientific papers
A three-nitrogen azole compound of synthetic method (by machine translation)
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, (2017/09/29)
The invention discloses a three-nitrogen azole compounds 1 - 4 - chlorophenyl -3 - (1 H - 1, 2, 4 - triazole -1 - yl) -1 - propylamine synthetic method, to 4 - benzoyl chloride as the starting material, after coupling, condensation, oximation, reduction r
Synthesis and Antifungal Activity of a Series of Novel 1,2-Disubstituted Propenones
Ogata, Masaru,Matsumoto, Hiroshi,Kida, Shiro,Shimizu, Sumio,Tawara, Katsuya,Kawamura, Yoshimi
, p. 1497 - 1502 (2007/10/02)
To find an antifungal agent other than those of the imidazole and triazole series, a new class of 1,2-disubstituted propenones I and II was prepared and tested for antifungal activity.Comparison of the structure-activity relationships showed that the conjugated structure of carbonyl and exomethylene groups in I and II plays an important role in potent antifungal acivity.However, it is noteworthy that compounds 53, 54, and 56, which have a hydroxymethyl or methoxymethyl group instead of an exo-methylene group in I, also showed potent activity.Although many compounds exhibited strong antifungal activity in vitro, none showed activity in vivo of oral efficacy against subacute systemic candidiasis in mice. '
