81244-53-3Relevant academic research and scientific papers
Asymmetric hydrogenation: Chiral bis(phosphine)rhodium catalysts with phenyl group derivatives
Yoshikuni, Tadatsugu,Bailar Jr., John C.
, p. 2129 - 2133 (2008/10/08)
Some attempts to achieve optically active products were carried out by new catalysts of the type [Rh(COD)(P*)2]+, where the chiral phosphorus ligands are α-naphthylphenyl(o- or p-tolyl)phosphine (NPTP), bis[phenyl(o- or p-tolyl)phosphino]ethane (BPTE), bis(α-naphthylphenylphosphino)ethane (BNPE), and 1-phenyl-1,2-bis(diphenylphosphino)ethane (R-PDPE). Optical yields of 50-75% ee (ee = enantiomeric excess) were obtained in the hydrogenation of acetamidoacrylic acid. The ortho isomer of the tolyl group gave a higher optical yield than the para one. Isoalcohols were effective solvents. It was found that these catalysts can be recovered and reused for asymmetric hydrogenation.
