81254-82-2

Upstream product

• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 119-36-8 methyl salicylate 

Downstream Products

• 148875-53-0 2-(2-Methoxy-ethoxymethoxy)-benzoyl chloride 
• 1025897-05-5 5-[(4-Fluoro-phenyl)-phenyl-amino]-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 1027016-08-5 3-{4-Ethoxycarbonyl-5-[2-(2-methoxy-ethoxymethoxy)-phenyl]-5-oxo-pentyloxy}-benzoic acid ethyl ester 
• 1027207-54-0 5-(Benzyl-phenyl-amino)-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 1026081-66-2 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-(3-nitro-phenoxy)-pentanoic acid ethyl ester 
• 1028256-11-2 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-(2-methoxy-phenoxy)-pentanoic acid ethyl ester 
• 1027238-84-1 5-(3-Chloro-phenoxy)-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 1026741-66-1 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-4-phenoxy-butyric acid ethyl ester 
• 1026233-36-2 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-phenylsulfanyl-pentanoic acid ethyl ester 
• 1028302-49-9 4-Benzyloxy-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-butyric acid ethyl ester 
• 1026937-46-1 2-[2-(2-Methoxy-ethoxymethoxy)-benzoyl]-5-phenoxy-pentanoic acid ethyl ester 
• 1028315-57-2 5-Benzyloxy-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 1027371-03-4 5-Cyclohexyloxy-2-[2-(2-methoxy-ethoxymethoxy)-benzoyl]-pentanoic acid ethyl ester 
• 161053-91-4 ethyl 3-[3-(4-hydroxy-2-oxo-2H-1-benzopyran-3-yl)propoxy]benzoate 

Relevant academic research and scientific papers

Preparation of 3-Acyl-3-cyclobutene-1,2-diones and Some Related Monoacetals

3-(Tri-n-butylstannyl)-3-cyclobutene-1,2-diones and 4-methyl-3-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione 2-ethylene acetal participate in palladium/copper-cocatalyzed cross-coupling with acyl halides and in palladium-catalyzed carbonylative cross-coupl

Inhibitors of the FEZ-1 metallo-β-lactamase

Metallo-β-lactamases (MBLs) catalyze the hydrolysis of β-lactams including penicillins, cephalosporins and carbapenems. Starting from benzohydroxamic acid (1) structure-activity studies led to the identification of selective inhibitors of the FEZ-1 MBL, e.g., 2,5-substituted benzophenone hydroxamic acid 17 has a Ki of 6.1 ± 0.7 μM against the FEZ-1 MBL but does not significantly inhibit the IMP-1, BcII, CphA or L1 MBLs.

A novel nonpeptide HIV-1 protease inhibitor: Elucidation of the binding mode and its application in the design of related analogs

HIV-1 protease has been identified as a significant target enzyme in AIDS research. While numerous peptide-derived inhibitors have been described, the identification of a nonpeptide inhibitor remains an important goal. Using an HIV-1 protease mass screening technique, 4-hydroxy-3-(3-phenoxypropyl)-2H-1- benzopyran-2-one (1) was identified as a nonpeptide competitive inhibitor of the enzyme. Employing a Monte Carlo-based docking procedure, the coumarin was docked in the active site of the enzyme, revealing a binding mode that was later confirmed by the X-ray crystal analysis. Several analogs were prepared to test the binding interactions and improve the overall binding affinity. The most active compound in the study was 4,7-dihydroxy-3-[4-(2- methoxyphenyl)butyl]-2H-1-benzopyran-2-one (31).