1,4-O-Didesmethyl rac-Niranthin is an intermediate in the synthesis of rac-Niranthin (N481000), a lignan compound derived from the plant Phyllanthus amarus. It is known for its anti-leishmanial activity and its ability to reduce uric acid concentrations through xanthine oxidase inhibition.
81263-83-4
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Basic information
- Product Name: 1,4-O-DidesMethyl rac-Niranthin
- Synonyms: 1,4-O-DidesMethyl rac-Niranthin;WTRAXKOXNKPSLF-IRXDYDNUSA-N
- CAS NO:81263-83-4
- Molecular Formula: C22H28O7
- Molecular Weight: 404.45352
- EINECS: N/A
- Product Categories: Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File: 81263-83-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 1,4-O-DidesMethyl rac-Niranthin(CAS DataBase Reference)
- NIST Chemistry Reference: 1,4-O-DidesMethyl rac-Niranthin(81263-83-4)
- EPA Substance Registry System: 1,4-O-DidesMethyl rac-Niranthin(81263-83-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 81263-83-4(Hazardous Substances Data)
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81263-83-4 Usage
Uses
Used in Pharmaceutical Industry:1,4-O-Didesmethyl rac-Niranthin is used as an intermediate in the synthesis of rac-Niranthin, which exhibits anti-leishmanial activity. It is employed for the development of treatments targeting Leishmaniasis, a disease caused by protozoan parasites of the genus Leishmania. 1,4-O-DidesMethyl rac-Niranthin acts by inducing topoisomerase I-mediated DNA-protein adduct formation in Leishmania cells, triggering apoptosis of cellular nucleases.
Additionally, 1,4-O-Didesmethyl rac-Niranthin is used as a precursor in the synthesis of rac-Niranthin, which has the potential to reduce uric acid concentrations through xanthine oxidase inhibition. This makes it a valuable compound in the development of treatments for hyperuricemia and related conditions, such as gout.
Check Digit Verification of cas no
The CAS Registry Mumber 81263-83-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,1,2,6 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.Calculate Digit Verification of CAS Registry Number 81263-83:
(7*8)+(6*1)+(5*2)+(4*6)+(3*3)+(2*8)+(1*3)=124
124 % 10 = 4
So 81263-83-4 is a valid CAS Registry Number.
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1,4-O-DidesMethyl rac-Niranthin
