812648-74-1

Basic information

• Product Name: 1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine
• Synonyms: 1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine
• CAS NO: 812648-74-1
• Molecular Weight: 258.407
• Mol File: 812648-74-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine(812648-74-1)
• EPA Substance Registry System: 1-benzyl-3-(1-methylpyrrolidin-2-yl)piperidine(812648-74-1)

Safety Data

• Hazardous Substances Data: 812648-74-1(Hazardous Substances Data)

Upstream product

• 812648-73-0 2-(1-benzyl-2-oxopiperidine-3-yl)pyrrolidin-1-carboxylic acid methyl ester 

Downstream Products

• 487-19-4 nicotirine 
• 5337-62-2 3-(1-methylpyrrolidin-2-yl)piperidine 

Relevant articles and documents

A new approach to nicotine: Symmetry consideration for synthesis design

A synthesis of nicotyrine (9), and hence formally racemic nicotine, was carried out by elaboration of the 1:1 adduct 2 of cycloocta-1,5-diene and chlorosulfonyl isocyanate (CISO2-NCO). Transformation of adduct 2 into carbamate 4 was followed by ozonolysis, tosylation, and NaH treatment, which led to pyrrolidinylpiperidinone 6. LiAIH4 Reduction, debenzylation, and aromatization yielded 2.