812652-84-9

Usage

Uses

Used in Pharmaceutical Industry:
METHYL 4,5-DIMETHOXY-1H-INDOLE-2-CARBOXYLATE is used as a tripeptidyl peptidase inhibitor for its ability to inhibit the activity of tripeptidyl peptidases. These enzymes play a crucial role in various biological processes, and their inhibition can have therapeutic benefits in treating certain diseases and conditions. By targeting and inhibiting tripeptidyl peptidases, METHYL 4,5-DIMETHOXY-1H-INDOLE-2-CARBOXYLATE may contribute to the development of novel drugs and therapies in the pharmaceutical industry.

Upstream product

• 86-51-1 2,3-dimethyoxybenzaldehyde 

Downstream Products

• 50536-49-7 4,5-dimethoxy-1H-indole-2-carboxylic acid 
• 812653-11-5 18-[4,5-dimethoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-octadecan-1-ol 
• 812653-10-4 16-[4,5-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indol-3-yl]hexadecan-1-ol 
• 812652-86-1 4,5-dimethoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde 
• 30933-67-6 4,5-dimethoxy-1H-indole 

Relevant academic research and scientific papers

Preparation method of methoxy-substituted methyl-1H-indole-2-carboxylate

The invention relates to the technical field of organic synthesis, and provides a preparation method of methoxy-substituted methyl-1H-indole-2-carboxylate. The preparation method comprises the following steps: mixing methoxy-substituted methyl(Z)-2-azido-3-phenyl acrylate, a ruthenium catalyst and tetrahydrofuran, and carrying out a cyclization reaction to obtain the methoxy-substituted methyl-1H-indole-2-carboxylate. According to the preparation method provided by the invention, the ruthenium catalyst is adopted for catalysis, and the methoxy-substituted methyl-1H-indole-2-carboxylate can beprepared without using high-toxicity toluene and high-toxicity xylene as solvents. The preparation method provided by the invention is relatively low in toxicity and relatively high in safety coefficient; and the yield of a product, namely the methoxy-substituted methyl-1H-indole-2-carboxylate purified by the method provided by the invention is relatively high and is 93% or above.

Synthesis of symmetrical and unsymmetrical diindolylmethanes via acid-catalysed electrophilic substitution reactions

A range of activated indole-2-carboxylate derivatives was prepared via the Hemetsberger indole synthesis. Vilsmeier formylation was explored to establish regioselectivity and to prepare a range of new indole carbaldehydes. The indole aldehydes were reduce

Effects of indole fatty alcohols on the differentiation of neural stem cell derived neurospheres

In a search for inducers of neuronal differentiation to treat neurodegenerative diseases such as Alzheimer's disease, a series of indole fatty alcohols (IFAs) were prepared, 13c (n = 18) was able to promote the differentiation of neural stem cell derived neurospheres into neurons at a concentration of 10 nM. Analysis of the expression of the Notch pathway genes in neurospheres treated during the differentiation phase with 13c (n = 18) revealed a significant decrease in the transcription of the Notch 4 receptor.

Tripeptidyl peptidase inhibitors

The invention is relative to a compound of formula (I) and its use as an inhibitor of the CCK-inactivating peptidase tripeptidyl peptidase (TPP II). The invention concerns in particular the treatment of eating disorder, obesity, psychotic syndrome and associated psychiatric disorders. It concerns also the cosmetic use of a compound (I) in particular to aid slimming.