812675-55-1Relevant articles and documents
Design and Synthesis of New Templates Derived from Pyrrolopyrimidine as Selective Multidrug-Resistance-Associated Protein Inhibitors in Multidrug Resistance
Wang, Shouming,Wan, Nan Chi,Harrison, John,Miller, Warren,Chuckowree, Irina,Sohal, Sukhjit,Hancox, Timothy C.,Baker, Stewart,Folkes, Adrian,Wilson, Francis,Thompson, Deanne,Cocks, Simon,Farmer, Hayley,Boyce, Anthony,Freathy, Caroline,Broadbridge, Jan,Scott, John,Depledge, Paul,Faint, Richard,Mistry, Prakash,Charlton, Peter
, p. 1339 - 1350 (2007/10/03)
In our continued effort to identify selective MRP1 modulators, we have developed two novel templates, 3 and 4, through rational drug design by identifying the key pharmacophore interaction at the 7-position of the pyrrolopyrimidine template 1. Further syn
