81281-58-5

Usage

Uses

Used in Pharmaceutical Industry:
7-Aminotheophylline is used as a bronchodilator for the treatment of respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD), due to its ability to relax bronchial smooth muscles and alleviate symptoms.
7-Aminotheophylline is also used as a diuretic and cardiac stimulant in the treatment of heart failure and edema, capitalizing on its effects to increase urine output and stimulate the heart.
These applications highlight 7-Aminotheophylline's multifaceted role in medicine, targeting both respiratory and cardiovascular conditions.

InChI:InChI=1/C7H9N5O2/c1-10-5-4(12(8)3-9-5)6(13)11(2)7(10)14/h3H,8H2,1-2H3

Upstream product

• 1076-22-8 3-methylxanthine 
• 120642-74-2 3-methyl-7-aminoxanthine 
• 120642-76-4 potassium salt of 1-methyl-7-aminoxanthine 
• 74-88-4 methyl iodide 
• 81281-59-6 7-benzylideneaminotheophylline 
• 58-55-9 theophylline 

Downstream Products

• 114811-71-1 7-benzoylaminotheophyllin 
• 115174-47-5 6,8-dimethyl-1,3-diphenylpyrido<6,1-f>xanthine 
• 115174-46-4 1,3,6,8-tetramethylpyrido<6,1-f>xanthine 
• 115174-49-7 4-acetyl-1,3,6,8-tetramethylpyrido<6,1-f>xanthine 
• 81281-59-6 7-benzylideneaminotheophylline 
• 58-55-9 theophylline 
• 16044-79-4 5,7-Dimethylpyrimido<4.5-e>-1,2,4-triazinedione, isofervenulin 

Relevant academic research and scientific papers

PURINES, PYRIMIDINES, AND CONDENSED SYSTEMS BASED ON THEM. V. N-AMINOGROUP AS A PROTECTING FUNCTION IN PRODUCTION OF UNSYMMETRICAL 1,3-DIALKYLXANTHINES FROM 3-METHYLXANTHINE

3-Methyl-7-aminoxanthine (yield 67percent) and 3-methyl-1,7-diaminoxanthine (7percent) were obtained by the amination of 3-methylxanthine by hydroxylamino-O-sulfonic acid in an alkaline medium.Alkylation of the 3-methyl-7-aminoxanthine potassium salt followed by removal of the N-amino group with nitrous acid led to the formation of 1-R-3-methylxanthines (R = C2H5, C6H5CH2, CH2CN, CH2CO2CH3) with good yields.

DIFFERENT MODES OF ALKALINE HYDROLYSIS OF FERVENULIN AND ISOFERVENULIN

Unlike rheumycin and fervenulin, isofervenulin and 3-methylisofervenulin are hydrolyzed by aqueous alkalies at the N(5)-C(6) bond.On acidification of the reaction mixture, the N-carboxy-N-methylcarbamoyltriazines formed are reconverted into the starting isofervenulins, and on basification (pH > 10) into methylaminotriazinecarboxamides.A by-product of the alkaline hydrolysis of isofervenulin is a product of the contraction of the uracil ring, namely imidazotriazinone-7a-carboxylic acid.